Please use this identifier to cite or link to this item: http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/3642
Title: Synthesis, characterization, antimicrobial and antibiofilm activity, and molecular docking analysis of NHC precursors and their Ag-NHC complexes
Authors: Ustun, Elvan
Sahin, Neslihan
Celik, Cem
Tutar, Ugur
Ozdemir, Namik
Gurbuz, Nevin
Ozdemir, Ismail
Ordu Üniversitesi
0000-0003-3371-9874
0000-0001-6325-0216
0000-0003-1498-4170
Keywords: N-HETEROCYCLIC CARBENE; BIOFILM FORMATION; STRUCTURAL-CHARACTERIZATION; CRYSTAL-STRUCTURES; ESCHERICHIA-COLI; SILVER(I); PROGRAM
Issue Date: 2021
Publisher: ROYAL SOC CHEMISTRY CAMBRIDGE
Citation: Ustun, E., Sahin, N., Celik, C., Tutar, U., Ozdemir, N., Gurbuz, N., Ozdemir, I. (2021). Synthesis, characterization, antimicrobial and antibiofilm activity, and molecular docking analysis of NHC precursors and their Ag-NHC complexes. Dalton Transactions, 50(42), 15400-15412.Doi:10.1039/d1dt02003j
Abstract: Microorganisms attach to surfaces and interfaces and form biofilms which create a sheltered area for host cell response. Therefore, biofilms provide troubles in fields such as medicine, food, and pharmaceuticals. Inhibition of formation of biofilms through hindering of quorum sensing could be a method for the production of new generation antibiotics. In this study, four new benzimidazole type NHC precursors (1-allyl-3-benzyl-5,6-dimethylbenzimidazolium chloride, 1-allyl-3-(2,4,6-trimethylbenzyl)-5,6-dimethylbenzimidazolium chloride, 1-allyl-3-(2,3,5,6-tetramethylbenzyl)-5,6-dimethylbenzimidazolium chloride, and 1-allyl-3-(2,3,4,5,6-pentamethylbenzyl)-5,6-dimethylbenzimidazolium chloride and Ag-NHC complexes of these molecules were synthesized and characterized by elemental analysis, FT-IR spectroscopy, H-1, and C-13{H-1} NMR spectroscopy, LC-MS, and single crystal crystallography. Antimicrobial and biofilm formation inhibition activities of the molecules were evaluated. In addition, the activities of the molecules were examined in detail by molecular docking analysis. According to the results obtained, higher activity was achieved with the complex molecules when compared with the benzimidazole derivative ligands.
Description: WoS Categories : Chemistry, Inorganic & Nuclear Web of Science Index : Science Citation Index Expanded (SCI-EXPANDED) Research Areas : Chemistry
URI: http://dx.doi.org/10.1039/d1dt02003j
https://www.webofscience.com/wos/woscc/full-record/WOS:000707138600001
https://pubmed.ncbi.nlm.nih.gov/34647935
http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/3642
ISBN: 1477-9226
1477-9234
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