Please use this identifier to cite or link to this item: http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/1934
Title: The diagnostic value of FNDC5/Irisin in Renal Cell Cancer
Authors: Altay, Diler Us
Alver, Ahmet
Karaguzel, Ersagun
Keha, Esref Edip
Mentese, Ahmet
Yaman, Serap Ozer
Ordu Üniversitesi
0000-0002-0465-8403
Keywords: Carcinoma; Renal Cell; FNDC5 protein; rat [Supplementary Concept]; Urologic Neoplasms
Issue Date: 2018
Publisher: BRAZILIAN SOC UROL, RUA BAMBINA, 153, RIO DE JANEIRO, 2251-050, BRAZIL
Abstract: Purposes: The aim of this study was to determine the diagnostic significance of fibronectin type III domain containing protein 5 (FNDC5)/Irisin levels in the sera of patients with renal cell cancer. Materials and Methods: In the study, 48 individuals were evaluated. The patient group included 23 subjects diagnosed with renal tumor, and the control group of 25 healthy individuals. Patients diagnosed with renal tumor received surgical treatment consisting of radical or partial nephrectomy. Blood specimens were collected and serum FNDC5/Irisin and carcinoembryonic antigen (CEA) levels were determined using enzymelinked immunosorbent assay (ELISA). Results: FNDC5/irisin and CEA levels in renal cancer patients were significantly higher compared with the control group (p=0.0001, p=0.009, respectively). Also, FNDC5 levels was more sensitive and specific than CEA levels. The best cut-off points for FNDC5/irisin were > 105pg/mL and CEA were > 2.67ng/mL for renal cancer. Conclusions: FNDC5/Irisin may be used as a diagnostic biomarker for renal cancer.
URI: http://doi.org/10.1590/S1677-5538.IBJU.2017.0404
http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/1934
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