Please use this identifier to cite or link to this item: http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/1654
Title: Is it Possible to Regain Lost Minerals to Initial Enamel Lesions Using Enamel Matrix Derivatives Combined with Casein Phosphopeptide Amorphous Calcium Phosphate: An in Vitro Study
Authors: Guler, Cigdem
Keskin, Gul
Yildirim, Sibel
Ordu Üniversitesi
0000-0002-2581-9050
Keywords: Casein phosphopeptide amorphous calcium phosphate; enamel matrix derivatives; enamel remineralization; fluoride; SEM-EDX
CPP-ACP; REMINERALIZATION; FLUORIDE; PEPTIDE
Issue Date: 2020
Publisher: AVES, BUYUKDERE CAD 105-9, MECIDIYEKOY, SISLI, ISTANBUL 34394, TURKEY
Abstract: Objective: This study aimed to assess the efficacy of enamel matrix derivatives (EMD) used in combination with casein phosphopeptide amorphous calcium phosphate (CPP-ACP) to recover minerals to the enamel after artificial caries formation. Methods: Fifty enamel samples were prepared from the buccal surfaces of extracted human third molars. The samples were divided into five groups: (G1) Untreated enamel samples (control), (G2) Application of 500 ppm sodium fluoride (NaF), (G3) CPP-ACP, (G4) EMD, and (G5) CPP-ACP + EMD. All of the samples were placed in an acidic buffer solution for 96 hours to simulate a carious lesion. Ca/P ratios were calculated using energy dispersive X-ray spectroscopy (EDX). After seven days of the remineralization procedure, the mineral contents of the samples were re-measured. All the data were analyzed statistically. Results: There were no statistically significant differences in the mineral contents of the samples between the groups after demineralization (p>0.05). The Ca/P ratios of G2, G3, G4, and G5 increased significantly (p<0.05) after remineralization. The highest levels of the Ca/P ratio were obtained in G5. Conclusion: Despite the limitations of this in vitro study, the combined use of CPP-ACP and EMD may increase the remineralization potential. Furthermore, this procedures may be an alternative for providing enamel remineralization in future clinical trials.
URI: http://doi.org/10.5152/eurjther.2020.19110
http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/1654
Appears in Collections:Pedodonti

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