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Title: | Evaluation of salivary total oxidant-antioxidant status and DNA damage of children undergoing fixed orthodontic therapy |
Authors: | Guler, Cigdem Gunes, Dilek Karabulut, Aysun Bay Otlu, Onder Ozturk, Firat Toy, Ebubekir Ordu Üniversitesi 0000-0001-5958-7609 0000-0002-2581-9050 |
Keywords: | OXIDATIVE STRESSRESIN MONOMERSWHOLE SALIVACAPACITYMARKERCARIES8-HYDROXYDEOXYGUANOSINECYTOTOXICITYCOMPOSITESAPOPTOSIS Total oxidant statusTotal antioxidant status8-Hydroxy-2 '-deoxyguanosine |
Issue Date: | 2015 |
Publisher: | E H ANGLE EDUCATION RESEARCH FOUNDATION, INC1615 BEACON ST, NEWTON N, MA 02468-1507 |
Abstract: | Objective: To determine the total oxidant status (TOS), total antioxidant status (TAS), and the 8-hydroxy-2'-deoxyguanosine (8-OHdG) levels and their interrelationship in the saliva of children undergoing fixed orthodontic therapy. Materials and Methods: Thirty children were randomly divided into three groups. The attachments were bonded to all of the teeth using three different orthodontic composites: Transbond XT, Kurasper F, and GrenGloo. The salivary levels of TOS, TAS, and 8-OHdG were determined three times, as follows: before treatment (T-1) and at 1 month (T-2) and 3 months (T-3) following appliance placement. All data were statistically analyzed. Results: There were no significant differences in TOS, TAS, and 8-OHdG within the same time periods among the three different orthodontic composites (P > .05). TAS in all composite groups decreased over time. These decreases were found to be significant for Kurasper F and GrenGloo at the T1 T3 and T2 T3 time periods (P < .05). In all composite groups 8-OHdG decreased between T1 and T2 (P < .05). However, 8-OHdG in all composite groups increased from T2 to T3. These differences in 8-OHdG were significant in Kurasper F and GrenGloo (P < .05). Conclusions: Fixed orthodontic appliances bonded with the tested composites did not increase the cytotoxicity markers in saliva. |
URI: | http://doi.org/10.2319/110113-798.1 http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/1644 |
Appears in Collections: | Pedodonti |
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