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Investigation of the Relationship between Inflammation and Oxidative Stress Markers and Treatment Response in First-Attack Major Depression Patients: A Follow-Up Study

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dc.contributor.author Emekdar, Gizem
dc.contributor.author Tas, Halil Ibrahim
dc.contributor.author Sehitoglu, Hilal
dc.date.accessioned 2024-03-15T12:14:09Z
dc.date.available 2024-03-15T12:14:09Z
dc.date.issued 2023
dc.identifier.citation Emekdar, G., Tas, HI., Sehitoglu, H. (2023). Investigation of the Relationship between Inflammation and Oxidative Stress Markers and Treatment Response in First-Attack Major Depression Patients: A Follow-Up Study. Turk. Psikiyatr. Derg., 34(2), 89-99. https://doi.org/10.5080/u26698 en_US
dc.identifier.issn 1300-2163
dc.identifier.uri http://dx.doi.org/10.5080/u26698
dc.identifier.uri https://www.webofscience.com/wos/woscc/full-record/WOS:001044267800004
dc.identifier.uri http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/4665
dc.description WoS Categories: Psychiatry en_US
dc.description Web of Science Index: Social Science Citation Index (SSCI) en_US
dc.description Research Areas: Psychiatry en_US
dc.description.abstract Objective: There is a need to biomarkers for major depression (MD). The goals of this study are to compare serum levels of oxidative stress markers malondialdehyde (MDA) and F2-isoprostane and inflammation markers tumor necrosis factor-alpha (TNF-& alpha;), interleukin-6 (IL-6) and C-reactive protein (CRP) between patients with first-episode MD and healthy controls, to investigate the change of these markers after treatment and to investigate the relationship between levels of these markers and treatment response.Method: Our study was performed in 30 first-episode MD patients and 30 healthy volunteers. During the clinical evaluation Hamilton Depression Rating Scale and Clinical Global Impression Scale were applied to the participants. Serum levels of markers were measured at the baseline and after 8 weeks of treatment.Results: Compared to the control group, first-episode MD patients had significantly higher IL-6, CRP and MDA levels and lower F2-isoprostane levels. There was no difference between the groups in terms of TNF-& alpha; levels. TNF-& alpha;, IL-6, MDA and F2-isoprostane levels decreased significantly after treatment, whereas there was no significant change in CRP levels with treatment. Baseline F2-isoprostane levels were found to be significantly higher in treatment responders than non -responders (p<0.05).Conclusion: In our study, it was shown that there are irregularities related to inflammatory processes and oxidative stress in MD, even in patients who had their first-episode and did not take medication, and these irregularities can be resolved after treatment. While there was a relationship between treatment response and baseline F2-isoprostane levels, there was no relationship with other biomarkers. en_US
dc.language.iso eng en_US
dc.publisher TURKIYE SINIR VE RUH SAGLIGI DERNEGI-YENISEHIR en_US
dc.relation.isversionof 10.5080/u26698 en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.subject Biomarkers, depression, inflammation, oxidative stress, treatment response en_US
dc.subject ANTIDEPRESSANT TREATMENT, PERIPHERAL CYTOKINE, LIPID-PEROXIDATION, METAANALYSIS, BIOMARKERS en_US
dc.title Investigation of the Relationship between Inflammation and Oxidative Stress Markers and Treatment Response in First-Attack Major Depression Patients: A Follow-Up Study en_US
dc.type article en_US
dc.relation.journal TURK PSIKIYATRI DERGISI en_US
dc.contributor.department Ordu Üniversitesi en_US
dc.identifier.volume 34 en_US
dc.identifier.issue 2 en_US
dc.identifier.startpage 89 en_US
dc.identifier.endpage 99 en_US


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