DSpace Repository

Evaluation of Serum CTNNβ1 and E-cadherin Levels in Hepatitis Patients

Show simple item record

dc.contributor.author Sahin, Arzu
dc.contributor.author Cetinkol, Yeliz
dc.contributor.author Cirrik, Selma
dc.contributor.author Calgin, Mustafa Kerem
dc.contributor.author Noyan, Tevfik
dc.contributor.author Taspinar, Numan
dc.date.accessioned 2024-03-15T11:51:22Z
dc.date.available 2024-03-15T11:51:22Z
dc.date.issued 2020
dc.identifier.citation Sahin, A., Cetinkol, Y., Cirrik, S., Calgin, MK., Noyan, T., Taspinar, N. (2020). Evaluation of Serum CTNNβ1 and E-cadherin Levels in Hepatitis Patients. VIRAL HEPAT. DERG., 26(3), 114-118. https://doi.org/10.4274/vhd.galenos.2020.2020.0026 en_US
dc.identifier.issn 1307-9441
dc.identifier.issn 2147-2939
dc.identifier.uri http://dx.doi.org/10.4274/vhd.galenos.2020.2020.0026
dc.identifier.uri https://www.webofscience.com/wos/woscc/full-record/WOS:000605350300002
dc.identifier.uri http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/4559
dc.description WoS Categories: Medicine, General & Internal en_US
dc.description Web of Science Index: Emerging Sources Citation Index (ESCI) en_US
dc.description Research Areas: General & Internal Medicine en_US
dc.description.abstract Objectives: Hepatitis B virus (HBV) infection is one of the leading causes of hepatocellular carcinoma, but the underlying molecular mechanisms are quite complex. In this study, the aim was to reveal the relationship of these parameters with HBV-DNA loads by evaluating serum CTNN beta, (beta-catenin) and E-cadherin levels in hepatitis B patients. Materials and Methods: In this study, between the dates of June 15.06.2018-December 30.12.2019, 75 people who were diagnosed with chronic hepatitis B constituted the patient group (n=75), and 75 people who were not diagnosed with chronic hepatitis B constituted the healthy control group (n=75). In this retrospective study using a random sampling method, the hepatitis B patient group was classified into 3 separate groups among themselves according to HBV-DNA loads; HBV-DNA-1 (x10(6)-10(8), n=25), HBV-DNA-2 (x10(3)-10(4), n=25) and HBV-DNA-3 (x10(1)-10(2), n=25). While the level of serum beta-catenin and E-cadherin, the main parameters in the study, were measured using the ELISA method with a commercial kit, the Chemiluminescent Microparticle Immunoassay method was used to evaluate the serological markers in the patients. HBV-DNA level was determined by real-time polymerase chain reaction. Results: In our study, the average age of individuals was 41.96 +/- 13.86 years in the control group and 36.72 +/- 16.3, 42.8 +/- 10.91 and 46.36 +/- 12.58 years in the HBV-DNA-1, 2, and 3 groups, respectively. The low age in the HBV-DNA-1 group compared to other groups was statistically significant (p=0.001; p<0.01). The values of E-cadherin were 44.57 +/- 29.61 ng/mL in the control group, and 42.76 +/- 23.23, 45.72 +/- 27.33 and 71.02 +/- 31.03 ng/mL in HBV-DNA-1, 2 and 3 groups, respectively. In addition, E-cadherin values were statistically significant in the HBV-DNA-3 group compared to other groups (p=0.001; p<0.01). The values of beta-catenin were 0.75 +/- 0.47 ng/ml. in the control group and were 1.05 +/- 0.63, 0.93 +/- 0.4 and 1.58 +/- 1.94 ng/mL in the DNA-1, 2, and 3 groups, respectively. The (-catenin value in the control group was found to be statistically significant compared to hepatitis B groups (p=0.001; p<0.01). Conclusion: E-cadherin values were found to be significantly lower in the HBV-DNA-1 group with the highest viral load. There may be a loss of E-cadherin due to severe inflammation in this group. Monitoring the levels of beta-catenin and E-cadherin may be important for evaluating the possible risk and prognosis for liver carcinoma in these patients. en_US
dc.language.iso eng en_US
dc.publisher GALENOS YAYINCILIK-FINDIKZADE en_US
dc.relation.isversionof 10.4274/vhd.galenos.2020.2020.0026 en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.subject Hepatitis B, beta-catenin, E-cadherin, viral load en_US
dc.subject HEPATOCELLULAR-CARCINOMA, CELL-ADHESION, BETA-CATENIN, PLAKOGLOBIN, EXPRESSION en_US
dc.title Evaluation of Serum CTNNβ1 and E-cadherin Levels in Hepatitis Patients en_US
dc.type article en_US
dc.relation.journal VIRAL HEPATIT DERGISI-VIRAL HEPATITIS JOURNAL en_US
dc.contributor.department Ordu Üniversitesi en_US
dc.contributor.authorID 0000-0002-7733-0177 en_US
dc.contributor.authorID 0000-0003-4236-6177 en_US
dc.identifier.volume 26 en_US
dc.identifier.issue 3 en_US
dc.identifier.startpage 114 en_US
dc.identifier.endpage 118 en_US


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse

My Account