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Hazelnut Has Potency on Wound Healing Associated with Immunohistochemical Biomarkers

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dc.contributor.author Cirakli, Alper
dc.contributor.author Erdem, Havva
dc.date.accessioned 2024-03-15T08:29:09Z
dc.date.available 2024-03-15T08:29:09Z
dc.date.issued 2023
dc.identifier.citation Çirakli, A., Erdem, H. (2023). Hazelnut Has Potency on Wound Healing Associated with Immunohistochemical Biomarkers. Indian J. Pharm. Educ. Res., 57(3), 748-755. https://doi.org/10.5530/ijper.57.3.91 en_US
dc.identifier.issn 0019-5464
dc.identifier.uri http://dx.doi.org/10.5530/ijper.57.3.91
dc.identifier.uri https://www.webofscience.com/wos/woscc/full-record/WOS:001137492300001
dc.identifier.uri http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/4224
dc.description WoS Categories: Education, Scientific Disciplines; Pharmacology & Pharmacy en_US
dc.description Web of Science Index: Science Citation Index Expanded (SCI-EXPANDED) en_US
dc.description Research Areas: Education & Educational Research; Pharmacology & Pharmacy en_US
dc.description.abstract Background: In this study, it was aimed to evaluate the impact of hazelnut on wound healing by using its immunohistochemical impacts on Claudin-5, Tumor Necrosis Factor-alpha (TNF-alpha), tumor Protein-63 (p63), and Insulin-like Growth Factor-1 (IGF-1) expression. Materials and Methods: Seventy-two male Wistar-Albino rats were used. Nine groups with 8 rats each group, and 3, 7, and 14 days groups were formed as oral, local, and control groups. Samples obtained from rats were evaluated with these immunohistochemical biomarkers. Results: Claudin-5 scores were found to be statistically significant in the oral group on all days (p=0.007, p=0.002, p=0,014). TNF-alpha scores were found to be statistically significant on the 3(rd) and 7(th) days in the local and oral groups (p=0.040, p=0.001). p63 scores were found to be statistically significant in the oral group when looking at the 14(th) day values (p=0.007). IGF-1 scores were found to be statistically significant on the 7(th) and 14(th) days in the local group (p=0.040). Conclusion: It was determined that hazelnut has positive impact on wound healing by stimulating the claudin-5, TNF-a, p63, and IGF-1 expression levels. en_US
dc.description.sponsorship Medical Faculty of Ordu University en_US
dc.language.iso eng en_US
dc.publisher ASSOC PHARMACEUTICAL TEACHERS INDIA-BANGALORE en_US
dc.relation.isversionof 10.5530/ijper.57.3.91 en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.subject Wound, Healing, Hazelnut, Immunohistochemical, Biomarkers en_US
dc.subject GROWTH-FACTOR-I, EXPRESSION en_US
dc.title Hazelnut Has Potency on Wound Healing Associated with Immunohistochemical Biomarkers en_US
dc.type article en_US
dc.relation.journal INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH en_US
dc.contributor.department Ordu Üniversitesi en_US
dc.identifier.volume 57 en_US
dc.identifier.issue 3 en_US
dc.identifier.startpage 748 en_US
dc.identifier.endpage 755 en_US


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