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Effects of deltamethrin and thiacloprid on cell viability, colony formation and DNA double-strand breaks in human bronchial epithelial cells

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dc.contributor.author Sekeroglu, Vedat
dc.contributor.author Erturk, Barbaros
dc.contributor.author Sekeroglu, Zulal Atli
dc.date.accessioned 2023-01-06T10:44:20Z
dc.date.available 2023-01-06T10:44:20Z
dc.date.issued 2021
dc.identifier.citation Sekeroglu, V., Erturk, B., Sekeroglu, ZA. (2021). Effects of deltamethrin and thiacloprid on cell viability, colony formation and DNA double-strand breaks in human bronchial epithelial cells. Chemosphere, 263, -.Doi:10.1016/j.chemosphere.2020.128293 en_US
dc.identifier.isbn 0045-6535
dc.identifier.isbn 1879-1298
dc.identifier.uri http://dx.doi.org/10.1016/j.chemosphere.2020.128293
dc.identifier.uri https://www.webofscience.com/wos/woscc/full-record/WOS:000595802200341
dc.identifier.uri https://pubmed.ncbi.nlm.nih.gov/33297235
dc.identifier.uri http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/3373
dc.description WoS Categories : Environmental Sciences Web of Science Index : Science Citation Index Expanded (SCI-EXPANDED) Research Areas : Environmental Sciences & Ecology en_US
dc.description.abstract Deltamethrin (DEL) and thiacloprid (THIA) are commonly used insecticides applied either separately or as a mixture. We aimed to investigate the effects of DEL and THIA on cell viability, proliferation and DNA damage in human bronchial epithelial cells (BEAS-2B) because their effects in lung cells are not known. Our results indicate that all concentrations of DEL and THIA statistically decreased colony formation, plating efficiency and survival fraction in a concentration-dependent manner in BEAS-2B cells expect the lowest concentration for 24 h. MTT assay showed that treatment of DEL + THIA increased the cytotoxicity at higher concentrations. DEL + THIA significantly induced the foci formation of phosphorylated H2AX protein and p53 binding protein 1 at the highest concentration (44 mu M DEL+666 mu M THIA) for 120 h. Because gH2AX foci number was still higher in the recovery group given an additional 24 h after 120 h, the recovery period was not sufficient for DNA double-strand breaks repair. (C) 2020 Elsevier Ltd. All rights reserved. en_US
dc.description.sponsorship Funding Orgs : Scientific and Technological Research Council of Turkey (TUBITAK) [115Z817] Funding Name Preferred : Scientific and Technological Research Council of Turkey (TUBITAK)(Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK)) Funding Text : This research was supported by The Scientific and Technological Research Council of Turkey (TUBITAK) (Project No: 115Z817). en_US
dc.language.iso eng en_US
dc.publisher PERGAMON-ELSEVIER SCIENCE LTD OXFORD en_US
dc.relation.isversionof 10.1016/j.chemosphere.2020.128293 en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.subject SISTER-CHROMATID EXCHANGES; COMMERCIAL FORMULATIONS; OCCUPATIONAL-EXPOSURE; DAMAGE; BLOOD; MOUSE; INSECTICIDES; LYMPHOCYTES; ABERRATIONS; PESTICIDES en_US
dc.subject Deltamethrin; Thiacloprid; Cytotoxicity; Proliferation; DNA damage And repair; Human bronchial cells en_US
dc.title Effects of deltamethrin and thiacloprid on cell viability, colony formation and DNA double-strand breaks in human bronchial epithelial cells en_US
dc.type article en_US
dc.relation.journal CHEMOSPHERE en_US
dc.contributor.department Ordu Üniversitesi en_US
dc.contributor.authorID 0000-0002-3552-3819 en_US
dc.contributor.authorID 0000-0002-8547-6571 en_US
dc.identifier.volume 263 en_US


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