dc.contributor.author |
Sekeroglu, Vedat |
|
dc.contributor.author |
Erturk, Barbaros |
|
dc.contributor.author |
Sekeroglu, Zulal Atli |
|
dc.date.accessioned |
2023-01-06T10:44:20Z |
|
dc.date.available |
2023-01-06T10:44:20Z |
|
dc.date.issued |
2021 |
|
dc.identifier.citation |
Sekeroglu, V., Erturk, B., Sekeroglu, ZA. (2021). Effects of deltamethrin and thiacloprid on cell viability, colony formation and DNA double-strand breaks in human bronchial epithelial cells. Chemosphere, 263, -.Doi:10.1016/j.chemosphere.2020.128293 |
en_US |
dc.identifier.isbn |
0045-6535 |
|
dc.identifier.isbn |
1879-1298 |
|
dc.identifier.uri |
http://dx.doi.org/10.1016/j.chemosphere.2020.128293 |
|
dc.identifier.uri |
https://www.webofscience.com/wos/woscc/full-record/WOS:000595802200341 |
|
dc.identifier.uri |
https://pubmed.ncbi.nlm.nih.gov/33297235 |
|
dc.identifier.uri |
http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/3373 |
|
dc.description |
WoS Categories : Environmental Sciences
Web of Science Index : Science Citation Index Expanded (SCI-EXPANDED)
Research Areas : Environmental Sciences & Ecology |
en_US |
dc.description.abstract |
Deltamethrin (DEL) and thiacloprid (THIA) are commonly used insecticides applied either separately or as a mixture. We aimed to investigate the effects of DEL and THIA on cell viability, proliferation and DNA damage in human bronchial epithelial cells (BEAS-2B) because their effects in lung cells are not known. Our results indicate that all concentrations of DEL and THIA statistically decreased colony formation, plating efficiency and survival fraction in a concentration-dependent manner in BEAS-2B cells expect the lowest concentration for 24 h. MTT assay showed that treatment of DEL + THIA increased the cytotoxicity at higher concentrations. DEL + THIA significantly induced the foci formation of phosphorylated H2AX protein and p53 binding protein 1 at the highest concentration (44 mu M DEL+666 mu M THIA) for 120 h. Because gH2AX foci number was still higher in the recovery group given an additional 24 h after 120 h, the recovery period was not sufficient for DNA double-strand breaks repair. (C) 2020 Elsevier Ltd. All rights reserved. |
en_US |
dc.description.sponsorship |
Funding Orgs : Scientific and Technological Research Council of Turkey (TUBITAK) [115Z817]
Funding Name Preferred : Scientific and Technological Research Council of Turkey (TUBITAK)(Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK))
Funding Text : This research was supported by The Scientific and Technological Research Council of Turkey (TUBITAK) (Project No: 115Z817). |
en_US |
dc.language.iso |
eng |
en_US |
dc.publisher |
PERGAMON-ELSEVIER SCIENCE LTD OXFORD |
en_US |
dc.relation.isversionof |
10.1016/j.chemosphere.2020.128293 |
en_US |
dc.rights |
info:eu-repo/semantics/openAccess |
en_US |
dc.subject |
SISTER-CHROMATID EXCHANGES; COMMERCIAL FORMULATIONS; OCCUPATIONAL-EXPOSURE; DAMAGE; BLOOD; MOUSE; INSECTICIDES; LYMPHOCYTES; ABERRATIONS; PESTICIDES |
en_US |
dc.subject |
Deltamethrin; Thiacloprid; Cytotoxicity; Proliferation; DNA damage And repair; Human bronchial cells |
en_US |
dc.title |
Effects of deltamethrin and thiacloprid on cell viability, colony formation and DNA double-strand breaks in human bronchial epithelial cells |
en_US |
dc.type |
article |
en_US |
dc.relation.journal |
CHEMOSPHERE |
en_US |
dc.contributor.department |
Ordu Üniversitesi |
en_US |
dc.contributor.authorID |
0000-0002-3552-3819 |
en_US |
dc.contributor.authorID |
0000-0002-8547-6571 |
en_US |
dc.identifier.volume |
263 |
en_US |