| dc.contributor.author |
Atli, Ilknur |
|
| dc.contributor.author |
Kelebekli, Latif |
|
| dc.date.accessioned |
2022-08-17T07:34:47Z |
|
| dc.date.available |
2022-08-17T07:34:47Z |
|
| dc.date.issued |
2019 |
|
| dc.identifier.uri |
http://doi.org/10.1016/j.tet.2019.130531 |
|
| dc.identifier.uri |
http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/2750 |
|
| dc.description.abstract |
The stereoselective synthesis of methyl-substituted inositol derivative is described. Diene diacetate which is a key compound was first prepared via three steps starting from 2-methyl-p-benzoquinone. Osmium-catalyzed regio- and stereoselective dihydroxylation of diene diacetate afforded cis-diol diasetate, which then produced tetra acetate via acetylation with Ac2O-pyridine. Oxidation and acetylation of the other alkene moiety in the compound gave a hexaacetate compound stereoselectively. Finally, the acetate groups were removed by NH3 leading to formation of the desired new methyl-substituted inositol derivative having a muco-inositol-type stereochemical pattern in the six-membered ring. Spectroscopic methods were used for characterization of all synthesized compounds. (C) 2019 Elsevier Ltd. All rights reserved. |
en_US |
| dc.language.iso |
eng |
en_US |
| dc.publisher |
PERGAMON-ELSEVIER SCIENCE LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND |
en_US |
| dc.relation.isversionof |
10.1016/j.tet.2019.130531 |
en_US |
| dc.rights |
info:eu-repo/semantics/openAccess |
en_US |
| dc.subject |
Inositol; Polycyclitol; Methyl-substituted muco-inositol-type pattern; Tertiary alcohol; Regioselective |
en_US |
| dc.title |
Stereoselective synthesis of a new methyl-substituted inositol derivative |
en_US |
| dc.type |
article |
en_US |
| dc.relation.journal |
TETRAHEDRON |
en_US |
| dc.contributor.department |
Ordu Üniversitesi |
en_US |