DSpace Repository

Magnetically responsive, sorafenib loaded alginate microspheres for hepatocellular carcinoma treatment

Show simple item record

dc.contributor.author Alpdemir, Sukran
dc.contributor.author Bayram, Cem
dc.contributor.author Denkbas, Emir Baki
dc.contributor.author Haberal, Erdem
dc.contributor.author Kara, Goknur
dc.contributor.author Vural, Tayfun
dc.date.accessioned 2022-08-17T07:06:54Z
dc.date.available 2022-08-17T07:06:54Z
dc.date.issued 2020
dc.identifier.uri http://doi.org/10.1049/iet-nbt.2020.0139
dc.identifier.uri http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/2690
dc.description.abstract This study aimed to develop sorafenib loaded magnetic microspheres for the treatment of hepatocellular carcinoma. To achieve this goal, superparamagnetic iron oxide nanoparticles (SPIONs) were synthesised and encapsulated in alginate microspheres together with an antineoplastic agent, sorafenib. In the study, firstly SPIONs were synthesised and characterised by dynamic light scattering, energy-dispersive X-ray spectroscopy, and scanning electron microscopy. Then, alginate-SPIONs microspheres were developed, and further characterised by electron spin resonance spectrometer and vibrating sample magnetometer. Besides the magnetic properties of SPIONs, alginate microspheres with SPIONs were also found to have magnetic properties. The potential use of microspheres in hyperthermia treatment was then investigated and an increase of about 4 degrees C in the environment was found out. Drug release studies and cytotoxicity tests were performed after sorafenib was encapsulated into the magnetic microspheres. According to release studies, sorafenib has been released from microspheres for 8 h. Cytotoxicity tests showed that alginate-SPION-sorafenib microspheres were highly effective against cancerous cells and promising for cancer therapy. en_US
dc.language.iso eng en_US
dc.publisher INST ENGINEERING TECHNOLOGY-IET, MICHAEL FARADAY HOUSE SIX HILLS WAY STEVENAGE, HERTFORD SG1 2AY, ENGLAND en_US
dc.relation.isversionof 10.1049/iet-nbt.2020.0139 en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.subject DRUG-DELIVERY; IN-VITRO; NANOPARTICLES; RELEASE en_US
dc.subject drug delivery systems; drugs; nanofabrication; magnetic particles; iron compounds; scanning electron microscopy; hyperthermia; biomedical materials; encapsulation; nanoparticles; light scattering; nanomagnetics; cellular biophysics; toxicology; cancer; nanomedicine; superparamagnetism; nanocomposites; magnetometry; paramagnetic resonance; X-ray chemical analysis; sorafenib loaded alginate microspheres; hepatocellular carcinoma treatment; sorafenib loaded magnetic microspheres; superparamagnetic iron oxide nanoparticles; dynamic light scattering; energy-dispersive X-ray spectroscopy; scanning electron microscopy; electron spin resonance spectrometer; vibrating sample magnetometer; hyperthermia treatment; drug release; alginate-SPION-sorafenib microspheres; antineoplastic agent; cytotoxicity tests; cancerous cells; time 8; 0 hour; Fe3O4 en_US
dc.title Magnetically responsive, sorafenib loaded alginate microspheres for hepatocellular carcinoma treatment en_US
dc.type article en_US
dc.relation.journal IET NANOBIOTECHNOLOGY en_US
dc.contributor.department Ordu Üniversitesi en_US
dc.contributor.authorID 0000-0001-8717-4668 en_US
dc.contributor.authorID 0000-0001-9504-5532 en_US
dc.contributor.authorID 0000-0003-2788-550X en_US
dc.identifier.volume 14 en_US
dc.identifier.issue 7 en_US
dc.identifier.startpage 617 en_US
dc.identifier.endpage 622 en_US


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse

My Account