dc.contributor.author |
Ayyildiz, Sema Nur |
|
dc.contributor.author |
Bayrak, Ahmet |
|
dc.contributor.author |
Bayrak, Tulin |
|
dc.contributor.author |
Isik, Sevil |
|
dc.contributor.author |
Karakahya, Murat |
|
dc.contributor.author |
Noyan, Tevfik |
|
dc.contributor.author |
Tas, Nilay |
|
dc.contributor.author |
Ustun, Burcu |
|
dc.contributor.author |
Yagan, Ozgur |
|
dc.date.accessioned |
2022-08-17T07:05:06Z |
|
dc.date.available |
2022-08-17T07:05:06Z |
|
dc.date.issued |
2014 |
|
dc.identifier.uri |
http://doi.org/10.5505/tjb.2014.79836 |
|
dc.identifier.uri |
http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/2681 |
|
dc.description.abstract |
Objective: The aim of the study was to investigate the changes of oxidative and anti-oxidative systems in the splanchnic area during carbon dioxide pneumoperitoneum and to determine whether the administration of dexmedetomidine has effects on these systems.
Methods: Forty rats were randomized into four groups: Group I; Control, Group II; No pneumoperitoneum, Dexmedetomidine administration, Group III; Pneumoperitoneum, no Dexmedetomidine administration and Group IV; Pneumoperitoneum and Dexmedetomidine administration 30 minutes before insufflation. The rats were rested 30 minutes after desufflation and blood samples were obtained for; ischaemia modified albumin (IMA), myeloperoxidase (MPO), advanced oxidation protein products (AOPP), catalase (CAT), paraoxonase (PON1) and platelet-activating factor acetylhydrolase (PAF-AH) analyses.
Results: When compared with the control group; the serum IMA levels significantly decreased in group II, and also increased in group III as compared to control (p<0.05). IMA levels were also significantly decreased in both groups II and IV as compared to group III (p<0.001). Serum MPO activity increased in group III as compared to control (p<0.05). Serum AOPP levels were significantly increased in group III as compared to group II (p<0.01) and decreased in group IV as compared to group III (p<0.01). Serum CAT activity was higher in group II than controls (p<0.05). Serum PON and plasma PAF-AH activities significantly decreased in grup III as compared to group II (p<0.05) and plasma PAF-AH activity were decreased in group III as compared to controls (p<0.05).
Conclusion: In conclusion, administration of dexmedetomidine; prior to ischemia reperfusion injury caused by pneumoperitoneum; reduces the oxidative injury and increases the antioxidant activity in the acute period. |
en_US |
dc.language.iso |
eng |
en_US |
dc.publisher |
WALTER DE GRUYTER GMBHGENTHINER STRASSE 13, D-10785 BERLIN, GERMANY |
en_US |
dc.relation.isversionof |
10.5505/tjb.2014.79836 |
en_US |
dc.rights |
info:eu-repo/semantics/closedAccess |
en_US |
dc.subject |
Dexmedetomidineischemia-reperfusion injuryoxidant-antioxidant systempneumoperitoneum |
en_US |
dc.title |
The effects of dexmedetomidine on oxidant - antioxidant systems in the experimental model of carbondioxide pneumoperitoneum |
en_US |
dc.type |
article |
en_US |
dc.relation.journal |
TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI |
en_US |
dc.contributor.department |
Ordu Üniversitesi |
en_US |
dc.contributor.authorID |
0000-0002-2628-7543 |
en_US |
dc.contributor.authorID |
0000-0002-7733-0177 |
en_US |
dc.contributor.authorID |
0000-0003-0472-2206 |
en_US |
dc.contributor.authorID |
0000-0003-1596-1421 |
en_US |
dc.identifier.volume |
39 |
en_US |
dc.identifier.issue |
4 |
en_US |
dc.identifier.startpage |
488 |
en_US |
dc.identifier.endpage |
494 |
en_US |