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The biomechanical and histological effects of platelet-rich plasma on fracture healing

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dc.contributor.author Bilge, Onur
dc.contributor.author Doral, Mahmut Nedim
dc.contributor.author Esen, Hasan
dc.contributor.author Goncu, Recep Gani
dc.contributor.author Guzel, Yunus
dc.contributor.author Kacira, Burkay K.
dc.contributor.author Karadag, Hakan
dc.contributor.author Karalezli, Nazim
dc.contributor.author Toker, Serdar
dc.date.accessioned 2022-08-17T07:02:52Z
dc.date.available 2022-08-17T07:02:52Z
dc.date.issued 2015
dc.identifier.uri http://doi.org/10.1007/s00167-013-2734-2
dc.identifier.uri http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/2664
dc.description.abstract Platelet-rich plasma (PRP) includes growth factors and proteins that accelerate and stimulate bone regeneration and tissue recovery. The aim of this study was to evaluate the effects of PRP on fracture healing in terms of biomechanics and histology. Seventy female rats were included in this experimental study. They were divided into three groups: Group I (no PRP, n = 30), Group II (PRP added, n = 30) and Group III (control, n = 10). The left femurs of the rats in Groups I and II were osteotomized and fixed by K-wires. Although no additional intervention was performed on Group I rats, PRP was applied to the fracture sites of Group II rats. The remaining ten rats were used as the control group of the biomechanical test (Group III). In the fourth week, nine femurs from Group I and ten femurs from Group II, and in the ninth week, nine femurs from each group were removed, and bone recovery was assessed histologically according to Modified Lane-Sandhu histological scoring criteria. Three-point bending test was applied to femurs for biomechanical evaluation in the ninth week. Histological healing was found to be significantly higher in Group II than in Group I (p < 0.05). Furthermore, biomechanical test results showed that healing quantity and bone strength were significantly better in Group II than in Group I (p < 0.05). PRP is a widely studied material in the physiology of fracture healing. The results of this study demonstrated the ameliorative biomechanical effects of PRP on fracture healing, in addition to accelerating the histological union of fractures. In the light of these results, PRP could be a viable alternative to accelerate the healing of fractures, late unions or non-unions. Prospective comparative study, Level II. en_US
dc.language.iso eng en_US
dc.publisher SPRINGERONE NEW YORK PLAZA, SUITE 4600 , NEW YORK, NY 10004, UNITED STATES en_US
dc.relation.isversionof 10.1007/s00167-013-2734-2 en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.subject ENDOTHELIAL-CELLSBONE-FORMATIONGROWTH-FACTORSREGENERATIONNONUNIONMODELPRGF en_US
dc.subject Platelet-rich plasma (PRP)PRGFFractureUnionBiomechanics en_US
dc.title The biomechanical and histological effects of platelet-rich plasma on fracture healing en_US
dc.type article en_US
dc.relation.journal KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY en_US
dc.contributor.department Ordu Üniversitesi en_US
dc.contributor.authorID 0000-0002-8555-0460 en_US
dc.identifier.volume 23 en_US
dc.identifier.issue 5 en_US
dc.identifier.startpage 1378 en_US
dc.identifier.endpage 1383 en_US


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