Why Helicobacter Pylori Eradication is Important?

Abstract

Background: It was aimed to determine the frequency of Helicobacter pylori (Hp) in patients who were made upper gastrointestinal system endoscopy and antrum biopsy due to dyspeptic complaints and to investigate the relation of Sydney classification criteria with Hp.

Materials and Methods: Patients who underwent esophagogastroduodenoscopy and taking antrum biopsy for dyspeptic complaints were included in the study between January 2015 and May 2017 at Ordu University Medical Faculty and Ordu State Hospital Endoscopy Units. Biopsy results of the patients were retrospectively analyzed.

Results: The number of the patients was 526. 47.7% (n = 251) of the patients were female and 52.3% (n = 275) were male. The mean age of the cases was 53.65 +/- 16.44 years (min 17 -max 93). 68.1% (n: 358) of the patients were Hp positive and 31.9% (n = 168) were Hp negative. In patients; the results of activation (+) in 75.9% (n: 399), intestinal metaplasia in 15.2% (n = 80) (+), glandular atrophy (+) in 8.6% (n = 45) were observed. All biopsies had inflammation. The severity of Inflammation in cases was 47.53% (n = 250) mild, 41.45% (n = 218) moderate, and 11.02% (n = 58) severe. When we evaluate the relationship between inflammation, activation, intestinal metaplasia and glandular atrophy with Hp, it was observed that all the criteria were significantly higher in patients with Hp (+) than Hp (-). There were severe inflammation in 3 (1.78%) of 168 patients with Hp (-) and 55 (15.4%) of 358 patients with Hp (+) (p:0,000). 320 (89.4%) of the 358 patients with Hp (+) and 79 (47%) of the 168 patients with Hp (-) had activation (p:0,000). Intestinal metaplasia was observed in 63 (17.6%) of the 358 patients with Hp (+) and 17 (10.1%) of 168 patients with Hp(-)(p:0,015). Glandular atrophy was observed in 41 (11.45%) of 358 patients with Hp(+) and in 4 (2.38%) of the 168 patients with Hp (-) (p: 0,000).

Conclusion: The prevalence of Hp in the community is still high. In patients with Hp (+), activation, inflammation severity, intestinal metaplasia and glandular atrophy rates are higher than those with Hp (-). Intestinal metaplasia and glandular atrophy are precancerous lesions. Early diagnosis and eradication of Hp may prevent the formation of precancerous lesions. Hp eradication can prevent not only stomach cancer but also many stomach diseases at the same time. Early diagnosis and eradication of Hp is important.