DSpace Repository

Can monocyte/HDL show inflammatory activity of isotretinoin treatment in acne patients?

Show simple item record

dc.contributor.author Onder, Sevda
dc.contributor.author Ozturk, Murat
dc.date.accessioned 2022-08-17T05:32:22Z
dc.date.available 2022-08-17T05:32:22Z
dc.date.issued 2020
dc.identifier.uri http://doi.org/10.1080/15569527.2020.1734815
dc.identifier.uri http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/2318
dc.description.abstract Aim: There are reports that isotretinoin causes some important diseases such as teratogenicity, inflammatory bowel disease and sacroiliitis by triggering inflammation. (Monocyte/HDL (high density lipoprotein) ratio) MHR is closely related to inflammation and is thought to be an indicator of atherosclerotic development. We aimed to investigate how isotretinoin (ISO) affects the immunoinflammatory response in acne patients. Materials and Methods: In this study, 116 nodulocystic acne patients who received ISO treatment for at least three months were evaluated retrospectively. ISO treatment was given to patients at a dose of 0.5-1 mg/kg. Pre-treatment and post-treatment white blood cell (WBC), neutrophil, lymphocyte, monocyte, platelet, mean platelet volume (MPV), platelet, plateletcrit, platelet distribution width (PDW), neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), total cholesterol, LDL cholesterol, triglyceride, HDL cholesterol and MHR were evaluated. Results: MPV and MHR values were significantly increased after 3 month treatment (p < 0.05). There was no significant change in NLR and PLR values (p > 0.05). There was a significant decrease in neutrophil count (p < 0.05). There were no significant changes in WBC, lymphocyte, monocyte, platelet, plateletcrit values (p > 0.05). Total cholesterol, LDL cholesterol and triglyceride levels were significantly increased after three months of treatment (p < 0.05). HDL cholesterol levels decreased significantly after three months of treatment (p < 0.05). Conclusion: We concluded that ISO treatment may trigger inflammation due to the increase in MPV and MHR value. MHR can show inflammation after ISO treatment. en_US
dc.language.iso eng en_US
dc.publisher TAYLOR & FRANCIS LTD, 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND en_US
dc.relation.isversionof 10.1080/15569527.2020.1734815 en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.subject Isotretinoin; monocyte; high density lipoprotein ratio; acne vulgaris en_US
dc.subject MEAN PLATELET VOLUME; LYMPHOCYTE RATIO; VULGARIS; RISK; ASSOCIATION; NEUTROPHIL; DECREASES en_US
dc.title Can monocyte/HDL show inflammatory activity of isotretinoin treatment in acne patients? en_US
dc.type article en_US
dc.relation.journal 39 en_US
dc.contributor.department Ordu Üniversitesi en_US
dc.contributor.authorID 0000-0002-4499-3724 en_US
dc.identifier.volume 2 en_US
dc.identifier.issue 111 en_US
dc.identifier.startpage 114 en_US


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse

My Account