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Please use this identifier to cite or link to this item: http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/5180
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dc.contributor.authorMentese, Ahmet-
dc.contributor.authorDogramaci, Seniz-
dc.contributor.authorDemir, Selim-
dc.contributor.authorYaman, Serap Ozer-
dc.contributor.authorInce, Imran-
dc.contributor.authorAltay, Diler Us-
dc.contributor.authorErdem, Mehmet-
dc.contributor.authorTurane, Ibrahim-
dc.contributor.authorAlver, Ahmet-
dc.date.accessioned2024-03-26T06:45:00Z-
dc.date.available2024-03-26T06:45:00Z-
dc.date.issued2021-
dc.identifier.citationMentese, A., Dogramaci, S., Demir, S., Yaman, SO., Ince, I., Altay, DU., Erdem, M., Turane, I., Alver, A. (2021). The effect of homocysteine on the expression of CD36, PPARγ, and C/EBPα in adipose tissue of normal and obese mice. Arch. Physiol. Biochem., 127(5), 437-444. https://doi.org/10.1080/13813455.2019.1648517en_US
dc.identifier.issn1381-3455-
dc.identifier.issn1744-4160-
dc.identifier.urihttp://dx.doi.org/10.1080/13813455.2019.1648517-
dc.identifier.urihttps://www.webofscience.com/wos/woscc/full-record/WOS:000480150000001-
dc.identifier.urihttp://earsiv.odu.edu.tr:8080/xmlui/handle/11489/5180-
dc.descriptionWoS Categories: Biochemistry & Molecular Biology; Biophysics; Endocrinology & Metabolism; Physiologyen_US
dc.descriptionWeb of Science Index: Science Citation Index Expanded (SCI-EXPANDED)en_US
dc.descriptionResearch Areas: Biochemistry & Molecular Biology; Biophysics; Endocrinology & Metabolism; Physiologyen_US
dc.description.abstractThe purpose of this study was to investigate the effect of homocysteine (Hcy) on CD36, PPAR gamma, and C/EBP alpha gene and protein expression in adipose tissue obtained from normal and high-calorie diet obesity models. CD36, PPAR gamma, and C/EBP alpha gene expression and protein levels in adipose tissue specimens were determined using the RT-PCR and ELISA methods, respectively. Significantly increased CD36 gene expression was observed in adipose tissue from obese mice, while Hcy significantly reduced CD36 gene expression in adipose tissue from normal and obese mice. PPAR gamma and C/EBP alpha gene expression levels decreased significantly in all groups compared to the normal group. In addition, levels of both PPAR gamma and C/EBP alpha gene expression were lower with Hcy supplementation compared to their own controls. In conclusion, Hcy's reduction of CD36 gene expression in adipose tissue may be one probable factor in hyperhomocysteinemia representing an independent risk factor for cardiovascular diseases.en_US
dc.description.sponsorshipKaradeniz Technical University Scientific Research Foundation [5323]en_US
dc.language.isoengen_US
dc.publisherTAYLOR & FRANCIS LTD-ABINGDONen_US
dc.relation.isversionof10.1080/13813455.2019.1648517en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAdipose tissue, cardiovascular diseases, CD36, C, EBP alpha, hyperhomocysteinemia, obesity, PPAR gammaen_US
dc.subjectDIET-INDUCED OBESITY, ADIPOCYTE DIFFERENTIATION, GENE-EXPRESSION, METABOLISM, ATHEROSCLEROSIS, ADIPOGENESIS, INFLAMMATION, STRAIN, CELLS, LIVERen_US
dc.titleThe effect of homocysteine on the expression of CD36, PPARγ, and C/EBPα in adipose tissue of normal and obese miceen_US
dc.typearticleen_US
dc.relation.journalARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRYen_US
dc.contributor.departmentOrdu Üniversitesien_US
dc.contributor.authorID0000-0002-9100-2479en_US
dc.contributor.authorID0000-0001-5643-3057en_US
dc.contributor.authorID0000-0002-1863-6280en_US
dc.contributor.authorID0000-0002-9617-6689en_US
dc.contributor.authorID0000-0003-3400-5494en_US
dc.contributor.authorID0000-0002-0465-8403en_US
dc.contributor.authorID0000-0003-2036-5317en_US
dc.contributor.authorID0000-0002-5089-0836en_US
dc.identifier.volume127en_US
dc.identifier.issue5en_US
dc.identifier.startpage437en_US
dc.identifier.endpage444en_US
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