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http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/5180| Title: | The effect of homocysteine on the expression of CD36, PPARγ, and C/EBPα in adipose tissue of normal and obese mice |
| Authors: | Mentese, Ahmet Dogramaci, Seniz Demir, Selim Yaman, Serap Ozer Ince, Imran Altay, Diler Us Erdem, Mehmet Turane, Ibrahim Alver, Ahmet Ordu Üniversitesi 0000-0002-9100-2479 0000-0001-5643-3057 0000-0002-1863-6280 0000-0002-9617-6689 0000-0003-3400-5494 0000-0002-0465-8403 0000-0003-2036-5317 0000-0002-5089-0836 |
| Keywords: | Adipose tissue, cardiovascular diseases, CD36, C, EBP alpha, hyperhomocysteinemia, obesity, PPAR gamma DIET-INDUCED OBESITY, ADIPOCYTE DIFFERENTIATION, GENE-EXPRESSION, METABOLISM, ATHEROSCLEROSIS, ADIPOGENESIS, INFLAMMATION, STRAIN, CELLS, LIVER |
| Issue Date: | 2021 |
| Publisher: | TAYLOR & FRANCIS LTD-ABINGDON |
| Citation: | Mentese, A., Dogramaci, S., Demir, S., Yaman, SO., Ince, I., Altay, DU., Erdem, M., Turane, I., Alver, A. (2021). The effect of homocysteine on the expression of CD36, PPARγ, and C/EBPα in adipose tissue of normal and obese mice. Arch. Physiol. Biochem., 127(5), 437-444. https://doi.org/10.1080/13813455.2019.1648517 |
| Abstract: | The purpose of this study was to investigate the effect of homocysteine (Hcy) on CD36, PPAR gamma, and C/EBP alpha gene and protein expression in adipose tissue obtained from normal and high-calorie diet obesity models. CD36, PPAR gamma, and C/EBP alpha gene expression and protein levels in adipose tissue specimens were determined using the RT-PCR and ELISA methods, respectively. Significantly increased CD36 gene expression was observed in adipose tissue from obese mice, while Hcy significantly reduced CD36 gene expression in adipose tissue from normal and obese mice. PPAR gamma and C/EBP alpha gene expression levels decreased significantly in all groups compared to the normal group. In addition, levels of both PPAR gamma and C/EBP alpha gene expression were lower with Hcy supplementation compared to their own controls. In conclusion, Hcy's reduction of CD36 gene expression in adipose tissue may be one probable factor in hyperhomocysteinemia representing an independent risk factor for cardiovascular diseases. |
| Description: | WoS Categories: Biochemistry & Molecular Biology; Biophysics; Endocrinology & Metabolism; Physiology Web of Science Index: Science Citation Index Expanded (SCI-EXPANDED) Research Areas: Biochemistry & Molecular Biology; Biophysics; Endocrinology & Metabolism; Physiology |
| URI: | http://dx.doi.org/10.1080/13813455.2019.1648517 https://www.webofscience.com/wos/woscc/full-record/WOS:000480150000001 http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/5180 |
| ISSN: | 1381-3455 1744-4160 |
| Appears in Collections: | Beslenme ve Diyetetik |
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