Please use this identifier to cite or link to this item: http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/5151
Title: The Effect of Humic Acid Substances on the Thyroid Function and Structure in Lead Poisoning
Authors: Sahin, A.
Iskender, H.
Kapakin, Terim K. A.
Altinkaynak, K.
Hayirli, A.
Gonultas, A.
Kaynar, O.
Ordu Üniversitesi
0000-0002-8063-4972
Keywords: Lead poisoning, humic acid substances, thyroid gland, chicken
EXPOSURE, TOXICITY, ENDOCRINE, HORMONE, WATER
Issue Date: 2016
Publisher: FACTA-FUNDACIO ARNCO CIENCIA TECNOLOGIA AVICOLAS-CAMPINAS
Citation: Sahin, A., Iskender, H., Kapakin, KAT., Altinkaynak, K., Hayirli, A., Gonultas, A., Kaynar, O. (2016). The Effect of Humic Acid Substances on the Thyroid Function and Structure in Lead Poisoning. Braz. J. Poult. Sci., 18(4), 649-653. https://doi.org/10.1590/1806-9061-2016-0299
Abstract: Lead (Pb) is a heavy metal, which adversely affects thyroid gland function and structure. Due to its high molecular weight and abundant functional groups, humic acid substances (HAS) can form chelates with heavy metals. The experiment was conducted to evaluate the prophylactic effect of HAS on thyroid hormone levels and histopathological lesions of laying hens exposed to lead (Pb) poisoning. After a week of adaptation, 192 Lohmann White laying hens (25 weeks of age) were fed one of four diets: a basal diet (BD) or the BD with HAS (0.15%), with Pb (0.3 g/kg), or with both. Experimental groups were replicated in 12 cages, with four hens each. Pb poisoning did not alter triiodothyronine (FT3; 3.22 +/- 0.20 ng/dL) or thyroxine (FT4; 0.71 +/- 0.08 ng/dL) concentrations, but caused a 167% increase in thyroid stimulating hormone (TSH) concentration. HAS supplementation returned the high TSH levels of hens exposed to Pb poisoning to normal values. Degenerative changes in the epithelial cells of the thyroid gland of the hens exposed to Pb poisoning were evidenced. Connective tissue cells in the interfollicular area and total amount of colloids with partially atrophic follicles were observed. These histopathological findings were less severe when HAS was added to the diet. In conclusion, HAS alleviates the effects of Pb poisoning on thyroid gland function and structure, possibly preventing its internalization by the tissue by forming chelates and exerting anti-inflammatory effects.
Description: WoS Categories: Agriculture, Dairy & Animal Science
Web of Science Index: Science Citation Index Expanded (SCI-EXPANDED)
Research Areas: Agriculture
URI: http://dx.doi.org/10.1590/1806-9061-2016-0299
https://www.webofscience.com/wos/woscc/full-record/WOS:000393599300013
http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/5151
ISSN: 1516-635X
1806-9061
Appears in Collections:Dahili Tıp Bilimleri

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