Please use this identifier to cite or link to this item: http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/5014
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dc.contributor.authorErgucuk, Hakan-
dc.contributor.authorIsik, Sevil-
dc.contributor.authorIflazoglu, Nidal-
dc.contributor.authorKayaalp, Cuneyt-
dc.contributor.authorSarac, Mehmet-
dc.contributor.authorGursul, Serdar-
dc.date.accessioned2024-03-26T06:24:47Z-
dc.date.available2024-03-26T06:24:47Z-
dc.date.issued2020-
dc.identifier.citationErgücük, H., Isik, S., Iflazoglu, N., Kayaalp, C., Saraç, M., Gürsul, S. (2020). The effect of trimethazidine on mortality in an experimental acute pancreatitis model. Turk. J. Gastroenterol., 31(8), 549-557. https://doi.org/10.5152/tjg.2020.18666en_US
dc.identifier.issn2148-5607-
dc.identifier.urihttp://dx.doi.org/10.5152/tjg.2020.18666-
dc.identifier.urihttps://www.webofscience.com/wos/woscc/full-record/WOS:000571470300001-
dc.identifier.urihttp://earsiv.odu.edu.tr:8080/xmlui/handle/11489/5014-
dc.descriptionWoS Categories: Gastroenterology & Hepatologyen_US
dc.descriptionWeb of Science Index: Science Citation Index Expanded (SCI-EXPANDED)en_US
dc.descriptionResearch Areas: Gastroenterology & Hepatologyen_US
dc.description.abstractBackground/Aims: Acute pancreatitis has a high morbidty and mortality. Its physiopathogenesis has not been enlightened up to the present. This study aims to investigate trimethazidine (antiischemic, antioxidant and cardioprotective agent) 's effects on the acute pancreatitis. Materials-Methods: In this study, four aqual groups are formed with 43 female Spraque-dawley type rats weighed between 230-300 gr (mean 265 gr). 0.9% NaCl is injected intraperitoneally after laparotomy to the Group 1 (n=6). Group 2 (n=6) is control group that without any intervention. Acute pancreatitis is formed in Group 3 (n=16) via injection of Na-taurocholate in the common bile duct. Group 4 (n=15) is being formed pancreatitis and treated with Trimetazidine. In group 4 Trimetazidine 10 mg/kg/day drugs were given, 30 minutes, 24 and 72 hours after formation of acute pancreatitis, in three equal doses by orogastric way. In all groups, the rats have been laparatomised 72 hours later under general anesthesia and pancreas tissues has been extracted and studied histopathologically. Amylase, lipase, lactate dehydrogenase, aspartate transaminase, alanine tranaminase levels in the rats serum and superoxide dismutase, catalase, glutathione, malondialdehyde, nitricoxide, protein carbonyl, glutathione peroxidase levels in the rats tissue also have been looked up. Results: Serum and tissue findings and histopathologically examination of the pancreas tissues show significant decrease in the treatment group compare to study group. Conclusion: Trimethazidine protects pancreas tissue and decreases the mortality by significantly lowering the biochemical and histopathological changes in the early stages of acute pancreatitis.en_US
dc.language.isoengen_US
dc.publisherAVES-SISLIen_US
dc.relation.isversionof10.5152/tjg.2020.18666en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcute pancreatitis, na-taurocholate, trimethazidineen_US
dc.subjectMITOCHONDRIAL-FUNCTION, TRIMETAZIDINE, INJURY, DISEASEen_US
dc.titleThe effect of trimethazidine on mortality in an experimental acute pancreatitis modelen_US
dc.typearticleen_US
dc.relation.journalTURKISH JOURNAL OF GASTROENTEROLOGYen_US
dc.contributor.departmentOrdu Üniversitesien_US
dc.contributor.authorID0000-0001-7727-602Xen_US
dc.identifier.volume31en_US
dc.identifier.issue8en_US
dc.identifier.startpage549en_US
dc.identifier.endpage557en_US
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