Please use this identifier to cite or link to this item: http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/4821
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dc.contributor.authorMutlu, Oguz-
dc.contributor.authorGumuslu, Esen-
dc.contributor.authorUlak, Guner-
dc.contributor.authorCelikyurt, Ipek Komsuoglu-
dc.contributor.authorKokturk, Sibel-
dc.contributor.authorKir, Hale Maral-
dc.contributor.authorAkar, Furuzan-
dc.contributor.authorErden, Faruk-
dc.date.accessioned2024-03-20T13:49:12Z-
dc.date.available2024-03-20T13:49:12Z-
dc.date.issued2012-
dc.identifier.citationMutlu, O., Gumuslu, E., Ulak, G., Celikyurt, IK., Kokturk, S., Kir, HM., Akar, F., Erden, F. (2012). Effects of fluoxetine, tianeptine and olanzapine on unpredictable chronic mild stress-induced depression-like behavior in mice. Life Sci., 91(25-26), 1252-1262. https://doi.org/10.1016/j.lfs.2012.09.023en_US
dc.identifier.issn0024-3205-
dc.identifier.issn1879-0631-
dc.identifier.urihttp://dx.doi.org/10.1016/j.lfs.2012.09.023-
dc.identifier.urihttps://www.webofscience.com/wos/woscc/full-record/WOS:000312361500002-
dc.identifier.urihttp://earsiv.odu.edu.tr:8080/xmlui/handle/11489/4821-
dc.descriptionWoS Categories: Medicine, Research & Experimental; Pharmacology & Pharmacyen_US
dc.descriptionWeb of Science Index: Science Citation Index Expanded (SCI-EXPANDED)en_US
dc.descriptionResearch Areas: Research & Experimental Medicine; Pharmacology & Pharmacyen_US
dc.description.abstractAims: Tianeptine is an atypical antidepressant drug that has a different mechanism of action than other antidepressants. Olanzapine is an atypical antipsychotic drug used for the treatment of schizophrenia. The present study was undertaken to investigate effects of chronic administration of tianeptine or olanzapine on unpredictable chronic mild stress (UCMS)-induced depression-like behavior in mice compared to a widely used SSRI antidepressant, fluoxetine. Main methods: Male inbred BALB/c mice were subjected to different kinds of stressors several times a day for 7 weeks and were treated intraperitoneally with tianeptine (5 mg/kg), olanzapine (2.5 mg/kg), fluoxetine (15 mg/kg) or vehicle for 5 weeks (n = 7-8 per group). Key findings: All the drugs tested prevented stress-induced deficit in coat state during UCMS procedure, in grooming behavior in the splash test, decreased the attack frequency in the resident intruder test and decreased the immobility time in the tail suspension test. In the open field test olanzapine had anxiolytic-like effects in both stressed and non-stressed mice. Tianeptine, olanzapine and fluoxetine decreased the enhanced levels of plasma ACTH and IL-6. Chronic treatment with tianeptine resulted in a significant increase in both total number and density of BrdU-labeled cells in stressed animals, while fluoxetine and olanzapine had a partial effect. Significance: The results of this study support the hypothesis that tianeptine can be as effective as fluoxetine for the treatment of depression in spite of the differences in the mechanism of action of these drugs. Moreover, olanzapine could be used effectively in psychotic patients with depression. (C) 2012 Elsevier Inc. All rights reserved.en_US
dc.language.isoengen_US
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD-OXFORDen_US
dc.relation.isversionof10.1016/j.lfs.2012.09.023en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDepression, Unpredictable chronic mild stress, Tianeptine, Olanzapine, Fluoxetine, Miceen_US
dc.subjectANTIDEPRESSANT-LIKE ACTION, TAIL SUSPENSION TEST, LONG-TERM, HIPPOCAMPAL NEUROGENESIS, INDUCED ANHEDONIA, PREDATOR STRESS, SPATIAL MEMORY, NOS INHIBITOR, MODEL, INVOLVEMENTen_US
dc.titleEffects of fluoxetine, tianeptine and olanzapine on unpredictable chronic mild stress-induced depression-like behavior in miceen_US
dc.typearticleen_US
dc.relation.journalLIFE SCIENCESen_US
dc.contributor.departmentOrdu Üniversitesien_US
dc.contributor.authorID0000-0003-0952-0742en_US
dc.contributor.authorID0000-0003-0895-3490en_US
dc.contributor.authorID0000-0001-5636-3300en_US
dc.contributor.authorID0000-0001-5636-3300en_US
dc.identifier.volume91en_US
dc.identifier.issue25-26en_US
dc.identifier.startpage1252en_US
dc.identifier.endpage1262en_US
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