The level of adenosine deaminase in the serum of patients who have positive Entamoeba coli

Abstract

Aim: The entomoeba coli which is an intestinal parasite is known as apatojen. However in some studies it has also been reported that it may be pathogenic. The Adenosine deaminase (ADA) is the key enzyme of purine metabolizm and controls the levels of adenosine and deoxy adenosine in the cell. The researchers have found that ADA is a marker of cellular immunity and the increased ADA serum in different diseases. In the study the comparison of ADA levels between the serums of the patients with detected Entamoeba coli (E. coli) and the control group is purposed. Methods: In this study the levels of ADA in the serums of 40 control groups and 35 patients who have E. coli are measured. When comparing the averages of the patients and control groups, the independent sample T test was also used. The mean age of the group is 37.97 +/- 5.06, 31 (89%) male and 4 (11%) of them are women. The mean age of healthy 40 people is 40.23 +/- 7.01, 31 (77%) males and 9 (23%) of them are women. Results: In the study according to the controls a significant increase is observed in ADA activity of the patient group. Conclusions: The findings seem to support the parasite's pathojen. In the studies which will be planned to determine whether the parasite is pathogenic or not, the detection of ADA values of Entemoeba coli diagnosed patients' before and after treatment will be guiding. In addition, the determination of ADA levels can give information about the immune mechanisms and we also can reach a conclusion that it can support the criterias for diagnosis and treatment of patients with positive Entemoeba coli.