Please use this identifier to cite or link to this item: http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/4188
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dc.contributor.authorKarakahya, Refika Hande-
dc.contributor.authorOzcan, Tuba Saziye-
dc.date.accessioned2024-03-15T08:25:03Z-
dc.date.available2024-03-15T08:25:03Z-
dc.date.issued2020-
dc.identifier.citationKarakahya, RH., Ozcan, TS. (2020). Salvage of the retinal ganglion cells in transition phase in Alzheimer's disease with topical coenzyme Q10: is it possible?. Graefes Arch. Clin. Exp. Ophthalmol., 258(2), 411-418. https://doi.org/10.1007/s00417-019-04544-3en_US
dc.identifier.issn0721-832X-
dc.identifier.issn1435-702X-
dc.identifier.urihttp://dx.doi.org/10.1007/s00417-019-04544-3-
dc.identifier.urihttps://www.webofscience.com/wos/woscc/full-record/WOS:000511928000023-
dc.identifier.urihttp://earsiv.odu.edu.tr:8080/xmlui/handle/11489/4188-
dc.descriptionWoS Categories: Ophthalmologyen_US
dc.descriptionWeb of Science Index: Science Citation Index Expanded (SCI-EXPANDED)en_US
dc.descriptionResearch Areas: Ophthalmologyen_US
dc.description.abstractPurpose The evaluation of the short-term effect of topically applied coenzyme Q10 (CoQ10) on retina and choroid in Alzheimer's disease (AD) was aimed in this study. Methods Randomized controlled study included a total of 93 patients, 62 of whom with AD. Thirty (32.3%) AD patients received treatment (Group 1), 32 (34.4%) AD patients observed without treatment (Group 2), and Group 3 included 31 (33.3%) healthy controls (HC). Neurological and ophthalmological examinations including optical coherence tomography (OCT) were executed. Results Retinal nerve fiber layer (RNFL) thickness in all quadrants increased following CoQ10 treatment in Group 1; however significant rise yielded in average and temporal quadrant RNFL thickness. Average and superonasal sector ganglion cell-inner plexiform layer (GCIPL) thickness increased significantly following CoQ10 treatment. The correlation analysis between difference in pre- and posttreatment OCT values in Group 1 revealed that rise in average RNFL thickness was inversely correlated with duration of the disease and rise in average GCIPL thickness and superonasal sector thickness was inversely correlated with severity of the disease. Conclusion Short-term topical CoQ10 resulted in improvement in AD related retinal ganglion cell (RGC) loss which may reflect the salvage of some RGCs in the reversible transitional phase. More bioavailability through intravitreal route of administration and longer duration of effect with sustained release forms may possibly help enhalting the RGC loss, especially incipience of neurodegenerative diseases.en_US
dc.language.isoengen_US
dc.publisherSPRINGER-NEW YORKen_US
dc.relation.isversionof10.1007/s00417-019-04544-3en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAlzheimer's disease, Coenzyme Q10, Neurodegeneration, Optical coherence tomographyen_US
dc.subjectOPTICAL COHERENCE TOMOGRAPHY, FIBER LAYER THICKNESS, COGNITIVE IMPAIRMENT, ASSOCIATION WORKGROUPS, DIAGNOSTIC GUIDELINES, NATIONAL INSTITUTE, ABNORMALITIES, RECOMMENDATIONS, DYSFUNCTION, DEMENTIAen_US
dc.titleSalvage of the retinal ganglion cells in transition phase in Alzheimer's disease with topical coenzyme Q10: is it possible?en_US
dc.typearticleen_US
dc.relation.journalGRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGYen_US
dc.contributor.departmentOrdu Üniversitesien_US
dc.identifier.volume258en_US
dc.identifier.issue2en_US
dc.identifier.startpage411en_US
dc.identifier.endpage418en_US
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