Please use this identifier to cite or link to this item: http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/3683
Title: A Multidisciplinary Approach to Coronavirus Disease (COVID-19)
Authors: Erturk, Aliye Gediz
Sahin, Arzu
Ay, Ebru Bati
Pelit, Emel
Bagdatli, Emine
Kulu, Irem
Gul, Melek
Mesci, Seda
Eryilmaz, Serpil
Ilter, Sirin Oba
Yildirim, Tuba
Ordu Üniversitesi
0000-0002-0935-4644
Keywords: DEPENDENT RNA-POLYMERASE; MOLECULAR DOCKING; IN-SILICO; CYTOKINE STORM; DOUBLE-BLIND; SONOCHEMICAL SYNTHESIS; POTENTIAL INHIBITORS; DRUG DESIGN; OPEN-LABEL; M-PRO
SARS-CoV-2; COVID-19; cytokine storm; immunotherapy; vaccine development; in-silico research; small drugs; repurposing drugs; dietary supplements; natural products
Issue Date: 2021
Publisher: MDPI BASEL
Citation: Erturk, AG., Sahin, A., Ay, EB., Pelit, E., Bagdatli, E., Kulu, I., Gul, M., Mesci, S., Eryilmaz, S., Ilter, SO., Yildirim, T. (2021). A Multidisciplinary Approach to Coronavirus Disease (COVID-19). Molecules, 26(12), -.Doi:10.3390/molecules26123526
Abstract: Since December 2019, humanity has faced an important global threat. Many studies have been published on the origin, structure, and mechanism of action of the SARS-CoV-2 virus and the treatment of its disease. The priority of scientists all over the world has been to direct their time to research this subject. In this review, we highlight chemical studies and therapeutic approaches to overcome COVID-19 with seven different sections. These sections are the structure and mechanism of action of SARS-CoV-2, immunotherapy and vaccine, computer-aided drug design, repurposing therapeutics for COVID-19, synthesis of new molecular structures against COVID-19, food safety/security and functional food components, and potential natural products against COVID-19. In this work, we aimed to screen all the newly synthesized compounds, repurposing chemicals covering antiviral, anti-inflammatory, antibacterial, antiparasitic, anticancer, antipsychotic, and antihistamine compounds against COVID-19. We also highlight computer-aided approaches to develop an anti-COVID-19 molecule. We explain that some phytochemicals and dietary supplements have been identified as antiviral bioproducts, which have almost been successfully tested against COVID-19. In addition, we present immunotherapy types, targets, immunotherapy and inflammation/mutations of the virus, immune response, and vaccine issues.
Description: WoS Categories : Biochemistry & Molecular Biology; Chemistry, Multidisciplinary Web of Science Index : Science Citation Index Expanded (SCI-EXPANDED) Research Areas : Biochemistry & Molecular Biology; Chemistry Open Access Designations : Green Published, gold
URI: http://dx.doi.org/10.3390/molecules26123526
https://www.webofscience.com/wos/woscc/full-record/WOS:000666658300001
https://pubmed.ncbi.nlm.nih.gov/34207756
http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/3683
ISBN: 1420-3049
Appears in Collections:Kimya

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