Please use this identifier to cite or link to this item: http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/3373
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dc.contributor.authorSekeroglu, Vedat-
dc.contributor.authorErturk, Barbaros-
dc.contributor.authorSekeroglu, Zulal Atli-
dc.date.accessioned2023-01-06T10:44:20Z-
dc.date.available2023-01-06T10:44:20Z-
dc.date.issued2021-
dc.identifier.citationSekeroglu, V., Erturk, B., Sekeroglu, ZA. (2021). Effects of deltamethrin and thiacloprid on cell viability, colony formation and DNA double-strand breaks in human bronchial epithelial cells. Chemosphere, 263, -.Doi:10.1016/j.chemosphere.2020.128293en_US
dc.identifier.isbn0045-6535-
dc.identifier.isbn1879-1298-
dc.identifier.urihttp://dx.doi.org/10.1016/j.chemosphere.2020.128293-
dc.identifier.urihttps://www.webofscience.com/wos/woscc/full-record/WOS:000595802200341-
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/33297235-
dc.identifier.urihttp://earsiv.odu.edu.tr:8080/xmlui/handle/11489/3373-
dc.descriptionWoS Categories : Environmental Sciences Web of Science Index : Science Citation Index Expanded (SCI-EXPANDED) Research Areas : Environmental Sciences & Ecologyen_US
dc.description.abstractDeltamethrin (DEL) and thiacloprid (THIA) are commonly used insecticides applied either separately or as a mixture. We aimed to investigate the effects of DEL and THIA on cell viability, proliferation and DNA damage in human bronchial epithelial cells (BEAS-2B) because their effects in lung cells are not known. Our results indicate that all concentrations of DEL and THIA statistically decreased colony formation, plating efficiency and survival fraction in a concentration-dependent manner in BEAS-2B cells expect the lowest concentration for 24 h. MTT assay showed that treatment of DEL + THIA increased the cytotoxicity at higher concentrations. DEL + THIA significantly induced the foci formation of phosphorylated H2AX protein and p53 binding protein 1 at the highest concentration (44 mu M DEL+666 mu M THIA) for 120 h. Because gH2AX foci number was still higher in the recovery group given an additional 24 h after 120 h, the recovery period was not sufficient for DNA double-strand breaks repair. (C) 2020 Elsevier Ltd. All rights reserved.en_US
dc.description.sponsorshipFunding Orgs : Scientific and Technological Research Council of Turkey (TUBITAK) [115Z817] Funding Name Preferred : Scientific and Technological Research Council of Turkey (TUBITAK)(Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK)) Funding Text : This research was supported by The Scientific and Technological Research Council of Turkey (TUBITAK) (Project No: 115Z817).en_US
dc.language.isoengen_US
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD OXFORDen_US
dc.relation.isversionof10.1016/j.chemosphere.2020.128293en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSISTER-CHROMATID EXCHANGES; COMMERCIAL FORMULATIONS; OCCUPATIONAL-EXPOSURE; DAMAGE; BLOOD; MOUSE; INSECTICIDES; LYMPHOCYTES; ABERRATIONS; PESTICIDESen_US
dc.subjectDeltamethrin; Thiacloprid; Cytotoxicity; Proliferation; DNA damage And repair; Human bronchial cellsen_US
dc.titleEffects of deltamethrin and thiacloprid on cell viability, colony formation and DNA double-strand breaks in human bronchial epithelial cellsen_US
dc.typearticleen_US
dc.relation.journalCHEMOSPHEREen_US
dc.contributor.departmentOrdu Üniversitesien_US
dc.contributor.authorID0000-0002-3552-3819en_US
dc.contributor.authorID0000-0002-8547-6571en_US
dc.identifier.volume263en_US
Appears in Collections:Moleküler Biyoloji ve Genetik Bölümü

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