Please use this identifier to cite or link to this item: http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/3328
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dc.contributor.authorCirrik, Selma-
dc.contributor.authorEsnafoglu, Erman-
dc.contributor.authorAdiguzel, Oznur-
dc.date.accessioned2023-01-06T08:36:10Z-
dc.date.available2023-01-06T08:36:10Z-
dc.date.issued2021-
dc.identifier.citationCirrik, S., Esnafoglu, E., Adiguzel, O. (2021). Evaluation of plasma GRP78 levels in patients with autism spectrum disorder. Dusunen Adam-Journal of Psychiatry and Neurological Sciences, 34(1), 83-88. Doi:10.14744/DAJPNS.2020.00123en_US
dc.identifier.isbn1018-8681-
dc.identifier.isbn1309-5749-
dc.identifier.urihttp://dx.doi.org/10.14744/DAJPNS.2020.00123-
dc.identifier.urihttps://www.webofscience.com/wos/woscc/full-record/WOS:000636467500009-
dc.identifier.urihttp://earsiv.odu.edu.tr:8080/xmlui/handle/11489/3328-
dc.descriptionWoS Categories : Psychiatry Web of Science Index : Emerging Sources Citation Index (ESCI) Research Areas : Psychiatry Open Access Designations : golden_US
dc.description.abstractObjective: The role of endoplasmic reticulum (ER) stress in the pathogenesis of autism spectrum disorder (ASD) has been previously reported in both experimental and postmortem studies. However, no circulating marker of ER stress has been identified so far in ASD patients. In the present study, the plasma level of glucose-regulated protein 78 (GRP78) was investigated in ASD patients as a potential marker for ER stress. Method: Plasma samples taken from healthy control subjects (n=26) and ASD patients (n=29) were used to evaluate circulating GRP78 levels. Plasma GRP78 concentrations were measured by ELISA. The severity of the disease in the ASD group was determined by the childhood autism rating scale. Results: There was no significant difference between the median values of plasma GRP78 levels in ASD (12.40) and healthy control groups (11.11) (p<0.218). Plasma GRP78 concentration was 12.81 +/- 4.90 ng/mL in the ASD group and was not significantly different from the control values (11.12 +/- 3.83 ng/mL). Conclusion: Although ER stress was associated with ASD, our results showed that plasma levels of GRP78 did not change in ASD patients. Our results suggest that GRP78 is not an appropriate circulatory marker to evaluate ER stress in ASD patients.en_US
dc.language.isoengen_US
dc.publisherKARE PUBL ISTANBULen_US
dc.relation.isversionof10.14744/DAJPNS.2020.00123en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectENDOPLASMIC-RETICULUM STRESS; BLOOD-BRAIN-BARRIER; ER STRESS; SCHIZOPHRENIA; EXPRESSION; OUTGROWTH; SCHEDULE; CHILDREN; DEATHen_US
dc.subjectAutism spectrum disorders; autism; endoplasmic reticulum stress; GRP78; pathogenesisen_US
dc.titleEvaluation of plasma GRP78 levels in patients with autism spectrum disorderen_US
dc.typearticleen_US
dc.relation.journalDUSUNEN ADAM-JOURNAL OF PSYCHIATRY AND NEUROLOGICAL SCIENCESen_US
dc.contributor.departmentOrdu Üniversitesien_US
dc.identifier.volume34en_US
dc.identifier.issue1en_US
dc.identifier.startpage83en_US
dc.identifier.endpage88en_US
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