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Title: Rosuvastatin versus Atorvastatin to prevent Contrast Induced Nephropathy in patients undergoing primary percutaneous coronary intervention (ROSA-CIN trial)
Authors: Kaya, Ahmet
Kurt, Mustafa
Tanboga, Ibrahim Hall
Isik, Turgay
Ekinci, Mehmet
Aksakal, Enbiya
Kaya, Yasemin
Topcu, Selim
Sevimli, Serdar
Ordu Üniversitesi
Keywords: Contrast-induced nephropathy statin ST-segment elevation myocardial infarction
Issue Date: 2013
Abstract: Aim We aimed to compare the incidence of contrast-induced nephropathy (CIN) between atorvastatin versus rosuvastatin in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary coronary angioplasty. Methods One hundred ninety-two consecutive patients, who underwent primary percutaneous intervention (p-PCI) with the diagnosis of STEMI, were included in the study. The patients were randomized to take atorvastatin 80 mg (n = 98) or rosuvastatin 40 mg (n = 94) before the procedure. Biochemical and complete blood count measurements were done at baseline and at 48 hours following admission. Results The incidence of CIN was 8.9% (n = 17) in the entire groups. The analysis performed between the statin groups revealed no statistical difference in any of the renal dysfunction indicators [baseline creatinine, baseline estimated glomerular filtration rate (eGFR), creatinine at 48 h, eGFR at 48 h, difference between baseline and 48 h creatinine, the per cent increase in the creatinine at 48 hours relative to basal creatinine] In STEMI patients undergoing primary PCI, only the amount of the contrast agent administered was determined to be an independent predictor for CIN (OR and 95% Cl: 1.08 (1.03-1.13), P <= 0.001). Left ventricular ejection fraction exhibited borderline statistical significance (OR and 95% Cl: 0.88 (0.77-1.01), P = 0.07). Conclusion Atorvastatin and rosuvastatin had similar efficacy in preventing CIN in patients with STEMI undergoing P-PCI.
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