Please use this identifier to cite or link to this item: http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/3188
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dc.contributor.authorSekeroglu, Vedat-
dc.contributor.authorSekeroglu, Zulal Atli-
dc.contributor.authorKefelioglu, Haluk-
dc.date.accessioned2022-09-06T10:43:47Z-
dc.date.available2022-09-06T10:43:47Z-
dc.date.issued2013-
dc.identifier.urihttp://doi.org/10.1002/tox.20746-
dc.identifier.urihttp://earsiv.odu.edu.tr:8080/xmlui/handle/11489/3188-
dc.description.abstractDeltamethrin (DEL) and thiacloprid (THIA) are two insecticides that are widely used in agriculture either separately or in combination. Studies on genotoxicity and cytotoxicity of TIA and the mixture of DEL and THIA insecticides have not been reported so far. Therefore, we investigated the cytotoxic and genotoxic effects of commercial formulations DEL and/or THIA in rat bone marrow cells, using mitotic index (MI), micronucleus (MN) and chromosome aberrations (CA) assay. In vivo cytokinesis-block micronucleus (CBMN) assay using cytochalasin-B in bone marrow cells was performed for the first time in this study. Rats were orally gavaged with a single dose of DEL (15 mg/kg), THIA (112.5 mg/kg) or DEL + THIA (15 + 112.5 mg/kg) for 24 h (acute treatments), or DEL (3 mg/kg/day), THIA (22.5 mg/kg/day) or DEL + THIA (3 + 22.5 mg/kg/day) for 30 days (subacute treatments). A corn oil vehicle control group and cyclophosphamide (50 mg/kg) positive control group were also included. All DEL and/or THIA treatments significantly decreased MI and binucleated (BN) cell numbers, and significantly increased CA, as compared to the vehicle control group. The results of CBMN assay indicated that the combination of DEL and THIA for both treatment times and the 30-day treatment with THIA alone caused a significant increase in micronucleus formation in BN cells. The present findings indicated the combined exposure of DEL and THIA showed genotoxic and cytotoxic effects more than those of individual exposure of DEL or THIA in rat bone marrow cells. © 2011 Wiley Periodicals, Inc. Environ Toxicol 28: 524–531, 2013.en_US
dc.language.isoengen_US
dc.publisherWILEY111 RIVER ST, HOBOKEN 07030-5774, NJen_US
dc.relation.isversionof10.1002/tox.20746en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectdeltamethrin, thiacloprid, chromosomal aberrations, micronucleus, rat bone marrowen_US
dc.titleCytogenetic effects of commercial formulations of deltamethrin and/or thiacloprid on wistar rat bone marrow cellsen_US
dc.typearticleen_US
dc.relation.journalENVIRONMENTAL TOXICOLOGYen_US
dc.contributor.departmentOrdu Üniversitesien_US
dc.contributor.authorID0000-0002-8547-6571en_US
dc.contributor.authorID0000-0002-7421-6037en_US
dc.contributor.authorID0000-0002-3552-3819en_US
dc.identifier.volume28en_US
dc.identifier.issue9en_US
dc.identifier.startpage524en_US
dc.identifier.endpage531en_US
Appears in Collections:Moleküler Biyoloji ve Genetik Bölümü

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