Please use this identifier to cite or link to this item:
http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/2685| Title: | Dickkopf-1 Levels in Turkish Patients with Bladder Cancer and its Association with Clinicopathological Features |
| Authors: | Benli, Erdal Gecit, Ilhan Gunes, Mustafa Kaba, Mehmet Kemik, Ahu Sarbay Pirincci, Necip Tok, Adem Yuksel, Mehmet Bilgehan Ordu Üniversitesi 0000-0001-7329-6971 0000-0002-5494-0984 0000-0002-5968-7981 0000-0003-2044-9086 |
| Keywords: | Bladder cancerDKK-1clinic-pathological featuresprognosisTurkey |
| Issue Date: | 2014 |
| Publisher: | ASIAN PACIFIC ORGANIZATION CANCER PREVENTIONAPJCP HEAD OFFICE, KOREAN NATL CANCER CENTER, 323 ILAN -RO, ILSANDONG-GU, GOYANG-SI, GYEONGGI-DO 410-769, SOUTH KOREA |
| Abstract: | Background: Evidence indicates that Dickkopf-1 (DKK-1) levels may be a biomarker for cancer risk. The aim of this study was to assess DKK-1 and its correlation with clinic-pathological features in patients with bladder cancer. Materials and Methods: DKK-1 levels were determined in serum samples from 90 patients with bladder cancer before transurethral tumor resection. The concentrations of DKK-1 were determined by using enzyme linked immune-sorbent assay (ELISA). Results: Elevated preoperative DKK-1 levels were associated with tumor stage (p<0.001), grade (p<0.001) and histological grade (p<0.001). Conclusions: The results of our study demonstrated that the level of serum DKK-1 is correlated with both disease progression and increase in the tumor grade. Preoperative serum DKK-1 elevation may thus represent a novel marker for the determination of bladder cancer and the detection of patients with a likely poor clinical outcome. |
| URI: | http://doi.org/10.7314/APJCP.2014.15.1.381 http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/2685 |
| Appears in Collections: | Cerrahi Tıp Bilimleri |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.