Please use this identifier to cite or link to this item: http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/2627
Title: Effect of insulin-like growth factor-1 and hyaluronic acid in experimentally produced osteochondral defects in rats
Authors: Alemdar, Celil
Atic, Ramazan
Erbil, Baris
Erdem, Havva
Ozkul, Emin
Yucel, Istemi
Ordu Üniversitesi
0000-0002-3074-0240
0000-0003-2149-8154
Keywords: ARTICULAR-CARTILAGE REPAIR; KNEE; OSTEOARTHRITIS; LESIONS; TISSUE; CELLS; TALUS
Cartilage; hyaluronic acid; insulin-like growth factor-1; osteochondral defect MeSH terms: Hyaluronic acid; cartilage; IGF-1; sports medicine; rats
Issue Date: 2016
Publisher: MEDKNOW PUBLICATIONS & MEDIA PVT LTD, B-9, KANARA BUSINESS CENTRE, OFF LINK RD, GHAKTOPAR-E, MUMBAI, 400075, INDIA
Abstract: Background: The common purpose of almost all methods used to treat the osteochondral injuries is to produce a normal cartilage matrix. However current methods are not sufficient to provide a normal cartilage matrix. For that reason, researchers have studied to increase the effectiveness of this methods using chondrogenic and chondroprotective molecules in recent experimental studies. Insulin-like growth factor-1 (IGF-1) and hyaluronic acid (HA) are two important agents used in this field. This study compared the effects of IGF-1 and HA in an experimental osteochondral defect in rat femora. Materials and Methods: The rats were divided into three groups ( n = 15 per group) as follows: The IGF-1 group, HA group, and control group. An osteochondral defect of a diameter of 1.5 mm and a depth of 2 mm was created on the patellar joint side of femoral condyles. The IGF-1 group received an absorbable gelatin sponge soaked with 15 g/15 l of IGF-1, and the HA group received an absorbable gelatin sponge soaked with 80 g HA. The control group received only an absorbable gelatin sponge. Rats were sacrificed at the 6 (th) week, and the femur condyles were evaluated histologically. Results: According to the total Mankin scale, there was a statistically significant difference between IGF-1 and HA groups and between IGF-1 and control groups. There was also a significant statistical difference between HA and control groups. Conclusion: It was shown histopathologically that IGF-1 is an effective molecule for osteochondral lesions. Although it is weaker than IGF-1, HA also strengthened the repair tissue.
URI: http://doi.org/10.4103/0019-5413.185607
https://pubmed.ncbi.nlm.nih.gov/27512224/
http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/2627
Appears in Collections:Cerrahi Tıp Bilimleri

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