Please use this identifier to cite or link to this item: http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/2607
Title: General Antibiotic Exposure Is Associated With Increased Risk of Developing Chronic Rhinosinusitis
Authors: Bleier, Benjamin S.
Busaba, Nicolas Y.
Gray, Stacey T.
Gregorio, Luciano L.
Guo, Rong
Holbrook, Eric H.
Korkmaz, Hakan
Maxfield, Alice Z.
Ordu Üniversitesi
0000-0002-5893-9032
0000-0003-0783-8861
Keywords: Antibiotics; side effects; microbiome; chronic rhinosinusitis; quality of life
NASAL POLYPS; P-GLYCOPROTEIN; MICROBIOME; RESISTANCE; MANAGEMENT; DIVERSITY; SECRETION; SINUSITIS; CHILDREN; DISEASE
Issue Date: 2017
Publisher: WILEY, 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
Abstract: Objective: Antibiotic use and chronic rhinosinusitis (CRS) have been independently associated with microbiome diversity depletion and opportunistic infections. This study was undertaken to investigate whether antibiotic use may be an unrecognized risk factor for developing CRS. Study Design: Case-control study of 1,162 patients referred to a tertiary sinus center for a range of sinonasal disorders. Methods: Patients diagnosed with CRS according to established consensus criteria (n = 410) were assigned to the case group (273 without nasal polyps [CRSsNP], 137 with nasal polyps [CRSwNP]). Patients with all other diagnoses (n = 752) were assigned to the control group. Chronic rhinosinusitis disease severity was determined using a validated quality of life (QOL) instrument. The class, diagnosis, and timing of previous nonsinusitis-related antibiotic exposures were recorded. Results were validated using a randomized administrative data review of 452 (38.9%) of patient charts. The odds ratio of developing CRS following antibiotic exposure were calculated, as well as the impact of antibiotic use on the subsequent QOL. Results: Antibiotic use significantly increased the odds of developing CRSsNP (odds ratio: 2.21, 95% confidence interval, 1.66-2.93, P < 0.0001) as compared to nonusers. Antibiotic exposure was significantly associated with worse CRS QOL scores (P = 0.0009) over at least the subsequent 2 years. These findings were confirmed by the administrative data review. Conclusion: Use of antibiotics more than doubles the odds of developing CRSsNP and is associated with a worse QOL for at least 2 years following exposure. These findings expose an unrecognized and concerning consequence of general antibiotic use.
URI: http://doi.org/10.1002/lary.26232
https://onlinelibrary.wiley.com/doi/full/10.1002/lary.26232
http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/2607
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