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http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/2558| Title: | Antioxidant Activity, Acetylcholinesterase, and Carbonic Anhydrase Inhibitory Properties of Novel Ureas Derived from Phenethylamines |
| Authors: | Aksu, Kadir Goksu, Suleyman Gulcin, Ilhami Naderi, Ali Ozgeris, Bunyamin Taslimi, Parham Ordu Üniversitesi 0000-0002-2729-2168 |
| Keywords: | Acetylcholinesterase; Butyrylcholinesterase; Carbonic anhydrase; Enzyme inhibition; Urea LYOPHILIZED AQUEOUS EXTRACT; GLUTATHIONE-S-TRANSFERASE; ISOENZYMES HCA I; POLYPHENOL CONTENTS; CAFFEIC ACID; ANTIRADICAL ACTIVITIES; PHENOLIC-COMPOUNDS; POTENT INHIBITOR; ESTER CAPE; DERIVATIVES |
| Issue Date: | 2016 |
| Publisher: | WILEY-V C H VERLAG GMBH, POSTFACH 101161, 69451 WEINHEIM, GERMANY |
| Abstract: | A series of ureas derived from phenethylamines were synthesized and evaluated for human carbonic anhydrase (hCA) I and II, acetylcholinesterase (AChE), and butyrylcholinesterase (BChE) enzyme inhibitory activities and antioxidant properties. The ureas were synthesized from the reactions of substituted phenethylamines with N,N-dimethylcarbamoyl chloride; then, the synthesized compounds were converted to their corresponding phenolic derivatives via O-demethylation. hCA I and II were effectively inhibited by the newly synthesized compounds, with K-i values in the range of 0.307-0.432nM for hCA I and 0.149-0.278nM for hCA II. On the other hand, the K-i parameters of these compounds for AChE and BChE were determined in the range of 0.129-0.434 and 0.095-0.207 nM, respectively. Phenolic ureas also showed good antioxidant activities. |
| URI: | http://doi.org/10.1002/ardp.201600183 https://onlinelibrary.wiley.com/doi/10.1002/ardp.201600183 http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/2558 |
| Appears in Collections: | Kimya |
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