Please use this identifier to cite or link to this item: http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/2475
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dc.contributor.authorAtmaca, Aysegul-
dc.contributor.authorElbistan, Mehmet-
dc.contributor.authorKasurka, Ceren Borcek-
dc.contributor.authorSekeroglu, Zulal Atli-
dc.date.accessioned2022-08-17T06:07:29Z-
dc.date.available2022-08-17T06:07:29Z-
dc.date.issued2019-
dc.identifier.urihttp://doi.org/10.1007/s10616-019-00345-y-
dc.identifier.urihttps://link.springer.com/article/10.1007%2Fs10616-019-00345-y-
dc.identifier.urihttp://earsiv.odu.edu.tr:8080/xmlui/handle/11489/2475-
dc.description.abstractVildagliptin and sitagliptin are commonly used antidiabetic drugs. Chromosomal aberration (CA), sister chromatid exchange (SCE) and cytokinesis-block micronucleus (CBMN) assays were employed to assess and compare cytotoxic and genotoxic effects of these drugs. Peripheral lymphocytes were exposed to 125 mu g/ml, 250 mu g/ml and 500 mu g/ml of vildagliptin and 250 mu g/ml, 500 mu g/ml and 1000 mu g/ml of sitagliptin for 24 h and 48 h with and without exogenous metabolic activation. At the end of the study, it was determined that these drugs and their metabolites had no genotoxic effects on CA, SCE and CBMN. On the other hand, parallel to the increase in dose, vildagliptin showed weak cytotoxicity on the mitotic index, and depending on its increase in dose; sitagliptin caused potential cytotoxicity and cytostatic effect on the mitotic index, nuclear division index and proliferation index. Due to their cytotoxic and cytostatic potential, these drugs inhibit cell proliferation.en_US
dc.language.isoengen_US
dc.publisherSPRINGER, VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDSen_US
dc.relation.isversionof10.1007/s10616-019-00345-yen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectVildagliptin; Sitagliptin; Antidiabetic; In vitro genotoxicity; Comparisonen_US
dc.titleIn vitro cytogenetic assessment and comparison of vildagliptin and sitagliptinen_US
dc.typearticleen_US
dc.contributor.departmentOrdu Üniversitesien_US
dc.contributor.authorID0000-0002-5772-9463en_US
dc.identifier.volumeCYTOTECHNOLOGYen_US
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