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http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/2336| Title: | Increased Serum Zonulin Levels as an Intestinal Permeability Marker in Autistic Subjects |
| Authors: | Ayyildiz, Sema Nur Cirrik, Selma Dagli, Abdullah Erdil, Abdullah Erturk, Emine Yurdakul Esnafoglu, Erman Noyan, Tevfik Ordu Üniversitesi 0000-0001-5366-647X 0000-0001-8474-0185 0000-0001-8685-1153 0000-0002-7733-0177 |
| Keywords: | SPECTRUM DISORDERS; GASTROINTESTINAL SYMPTOMS; CELIAC-DISEASE; LARAZOTIDE ACETATE; GLUTEN CHALLENGE; CHILDREN; BARRIER; PATHOPHYSIOLOGY; ASSOCIATION; RELATIVES |
| Issue Date: | 2017 |
| Publisher: | MOSBY-ELSEVIER, 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA |
| Abstract: | Objective To evaluate the serum levels of zonulin, which regulates tight junctions between enterocytes and is a physiological modulator controlling intestinal permeability, in patients with autism spectrum disorders (ASDs). Study design Serum zonulin levels were determined in 32 patients with ASD and 33 healthy controls using an enzyme-linked immunosorbent assay. The severity of ASD symptoms was assessed with the Childhood Autism Rating Scale. Results Serum zonulin levels were significantly higher in the patients with ASD (122.3 +/- 98.46 ng/mL) compared with the healthy controls (41.89 +/- 45.83 ng/mL). There was a positive correlation between zonulin levels and Childhood Autism Rating Scale score when all subjects were assessed (r = 0.523; P <.001). Conclusions This study suggests that zonulin, which regulates intestinal permeability, plays a role in the development of symptoms of ASD. |
| URI: | http://doi.org/10.1016/j.jpeds.2017.04.004 http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/2336 |
| Appears in Collections: | Dahili Tıp Bilimleri |
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