Evaluation of serum uric levels in migraine

Abstract

Objective In our study, the aim was to identify the serum uric acid levels, a marker of oxidative stress, according to migraine subtypes (aura/without aura and episodic/chronic migraine). Method The study included 300 migraine patients and 150 healthy controls for a total of 450 individuals. Migraine and subtypes were diagnosed according to International Classification of Headache Disorders-2013 criteria. Patients were evaluated during attendance at the neurology clinic. Results Our patient group was 77.0% female and disease duration was 9.2 +/- 7.2 years. Our control group comprised 77.3% females. The age intervals in the patient and control groups were 36.4 +/- 10.4 years and 36.0 +/- 8.1 years. There was no statistically significant difference between our control and patient groups in terms of age and gender (p = .937 andp = .655). The serum UA, ferritin, and urea levels in our patient group were found to be significantly low compared to the healthy control group (p < .001). The serum UA levels in the migraine and control groups were 3.7 +/- 0.7 and 4.6 +/- 0.7 mg/dL, respectively (p < .001). There were no statistically significant differences observed between serum uric acid levels and other blood parameters between aura/without aura and episodic/chronic migraine subtypes (p > .05). Conclusion Our study supports the hypothesis that the oxidative stress marker of serum uric acid levels may be associated with migraine diagnosis, concluding that serum uric acid levels were not significant for migraine subtypes.