Relationship between glomerular filtration rate with uric acid and neutrophil to lymphocyte ratioin diabetic patients

Abstract

Aim: In this study we aimed to investigate the relationship between uric acid (UA) and neutrophil-lymphocyte ratio (NLO) with glomerular filtration rate (GFR) in diabetic patients. Material and Method: 355 diabetic patients were included in this study. Patients with gout, liver fatigue, coronary artery disease, heart failure, cancer disease, polycythemia, hypothyroidism, sarcoidosis, obesity, rheumatic diseases and active infection were excluded from the study. The biochemistry and complete blood count tests were recorded. GFR were calculated by the formula of Modification of Diet in Renal Disease. 24-hour urine microalbumin and protein levels were measured. Results: The patients with estimated GFR<60 were compared to the patients with e-GFR>60. The patients with e-GFR>60 were older and had higher NLR ratio, UA levels; more proteinuria-microalbuminuria. The age, UA levels and microalbuminuria was determined as e-GFR independent predictors. It was detected that when UA value was taken as >5.70mg/dl, e-GFR<60 ml/min/1.73m2 was demonstrated by the sensitivity of 80% and the specifity of 75% (AUC:0.863, 95% CI 0.785-0.941, p<0.001). Discussion: The high level of UA can be used as one of the independent predictors of e-GFR<60 ml/min/1.73 m2 in patients with DM. Although there is significant negative correlation between e-GFR and NLR, this doesn't predict e-GFR<60 mL/min/1.73m2.