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http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/2092| Title: | Rutin ameliorates methotrexate induced hepatic injury in rats |
| Authors: | Erdogan, Esra Gurgor, Pinar Naile Ilgaz, Yasin Oztas, Emin Oztas, Yesim Topal, Turgut Ordu Üniversitesi 0000-0002-4154-4675 0000-0002-5573-9932 0000-0002-8638-9744 |
| Keywords: | MethotrexateRutinDrug EffectsLiverRats OXIDATIVE STRESSINDUCED HEPATOTOXICITYANTIOXIDANTTOXICITYACIDPREVENTIONQUERCETINTISSUES |
| Issue Date: | 2015 |
| Publisher: | ACTA CIRURGICA BRASILEIRAALAMEDA RIO CLARO, 179-41, SAO PAULO, SP 01332-010, BRAZIL |
| Abstract: | PURPOSE: To investigate the possible protective effect of rutin on methotrexate induced hepatotoxicity in rats. METHODS: Twenty-two rats were divided into three experimental groups; Control-saline, Mtx, Mtx+Rutin. Hepatic tissue was taken for histological assessment and biochemical assays. Oxidative stress parameters malondialdehyde (MDA), glutathione peroxidase (GSHPx) and superoxide dismutase (SOD) were investigated. Liver markers aspartate aminotransferase (AST), alanine aminotransferase (ALT) were analyzed in serum. RESULTS: Mtx+Rutin group showed lower histological injury compared to Mtx group, MDA and ALT levels were increased, while SOD and GSH-Px were decreased in Mtx group compared with Control-saline group. MDA and ALT levels were increased, while SOD and GSH-Px were decreased in Mtx group, compared with Mtx + Rutin group. Serum AST levels were similar among the groups. CONCLUSION: Rutin may be a potential adjuvant drug to reduce the hepatic side effects observed during Mtx therapy for various clinical conditions. |
| URI: | http://doi.org/10.1590/S0102-865020150110000009 http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/2092 |
| Appears in Collections: | Temel Tıp Bilimleri |
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