1. Ordu Üniversitesi Açık Arşiv Sistemi
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  3. Tıp Fakültesi
  4. Temel Tıp Bilimleri
Please use this identifier to cite or link to this item: http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/2092
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dc.contributor.authorErdogan, Esra-
dc.contributor.authorGurgor, Pinar Naile-
dc.contributor.authorIlgaz, Yasin-
dc.contributor.authorOztas, Emin-
dc.contributor.authorOztas, Yesim-
dc.contributor.authorTopal, Turgut-
dc.date.accessioned2022-08-16T12:02:12Z-
dc.date.available2022-08-16T12:02:12Z-
dc.date.issued2015-
dc.identifier.urihttp://doi.org/10.1590/S0102-865020150110000009-
dc.identifier.urihttp://earsiv.odu.edu.tr:8080/xmlui/handle/11489/2092-
dc.description.abstractPURPOSE: To investigate the possible protective effect of rutin on methotrexate induced hepatotoxicity in rats. METHODS: Twenty-two rats were divided into three experimental groups; Control-saline, Mtx, Mtx+Rutin. Hepatic tissue was taken for histological assessment and biochemical assays. Oxidative stress parameters malondialdehyde (MDA), glutathione peroxidase (GSHPx) and superoxide dismutase (SOD) were investigated. Liver markers aspartate aminotransferase (AST), alanine aminotransferase (ALT) were analyzed in serum. RESULTS: Mtx+Rutin group showed lower histological injury compared to Mtx group, MDA and ALT levels were increased, while SOD and GSH-Px were decreased in Mtx group compared with Control-saline group. MDA and ALT levels were increased, while SOD and GSH-Px were decreased in Mtx group, compared with Mtx + Rutin group. Serum AST levels were similar among the groups. CONCLUSION: Rutin may be a potential adjuvant drug to reduce the hepatic side effects observed during Mtx therapy for various clinical conditions.en_US
dc.language.isoengen_US
dc.publisherACTA CIRURGICA BRASILEIRAALAMEDA RIO CLARO, 179-41, SAO PAULO, SP 01332-010, BRAZILen_US
dc.relation.isversionof10.1590/S0102-865020150110000009en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMethotrexateRutinDrug EffectsLiverRatsen_US
dc.subjectOXIDATIVE STRESSINDUCED HEPATOTOXICITYANTIOXIDANTTOXICITYACIDPREVENTIONQUERCETINTISSUESen_US
dc.titleRutin ameliorates methotrexate induced hepatic injury in ratsen_US
dc.typearticleen_US
dc.relation.journalACTA CIRURGICA BRASILEIRAen_US
dc.contributor.departmentOrdu Üniversitesien_US
dc.contributor.authorID0000-0002-4154-4675en_US
dc.contributor.authorID0000-0002-5573-9932en_US
dc.contributor.authorID0000-0002-8638-9744en_US
dc.identifier.volume30en_US
dc.identifier.issue11en_US
dc.identifier.startpage778en_US
dc.identifier.endpage784en_US
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