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Title: | Effects of chronic administration of adipokinetic and hypertrehalosemic hormone on animal behavior, BDNF, and CREB expression in the hippocampus and neurogenesis in mice |
Authors: | Akar, Furuzan Erden, Faruk Gumuslu, Esen Kaya, Havva Kokturk, Sibel Mutlu, Oguz Tanyeri, Pelin Ulak, Guner 0000-0001-5636-3300 0000-0002-2987-5834 0000-0003-0952-0742 |
Keywords: | adipokinetic hormone; animal behavior; mice; neurogenesis; neurotrophic factors IDENTIFICATION; GENE; INTEGRATION; LOCOMOTION; ENERGY |
Issue Date: | 2016 |
Publisher: | WILEY, 111 RIVER ST, HOBOKEN 07030-5774, NJ USA |
Abstract: | Neurosecretory cells in corpus cardiacum of insects synthesize a set of hormones that are called adipokinetic, hypertrehalosaemic or hyperprolinaemic, depending on insect in question. This study investigated effects of chronic administration of Anax imperator adipokinetic hormone (Ani-AKH), Libellula auripennis adipokinetic hormone (Lia-AKH), and Phormia-Terra hypertrehalosaemic hormone (Pht-HrTH) on depression, anxiety, analgesy, locomotion in forced swimming (FST), elevated plus-maze (EPM), hot plate, and locomotor activity tests. Ani-AKH (1 and 2 mg/kg), Lia-AKH (1 and 2 mg/kg), and Pht-HrTH (1 and 2 mg/kg) had antidepressant effects in forced swimming test. Lia-AKH (2 mg/kg) and Pht-HrTH (1 and 2 mg/kg) had anxiolytic effects when given chronically in elevated plus-maze test. Ani-AKH (1 and 2 mg/kg) and Pht-HrTH (2 mg/kg) had antinociceptive effects in hot plate test in male balb-c mice. Ani-AKH (2 mg/kg), Lia-AKH (1 and 2 mg/kg), and Pht-HrTH had locomotion-enhancing effects in locomotor activity test in male balb-c mice. Drug treatment significantly increased brain-derived neurotrophic factor (BDNF) and cyclic adenosine monophosphate (cAMP) response element binding protein (CREB) gene expression levels compared to control levels. Pht-HrTH and Ani-AKH groups had significantly increased numbers of BrdU-labeled cells, while neurodegeneration was lower in the Pht-HrTH group. Our study showed that AKH/RPCH family peptides may be used in treatment of psychiatric illness such as depression and anxiety, in treatment of pain and in diseases related to locomotion system. AKH/RPCH family peptides increase neurotrophic factors in brain and have potential proliferative and neuroprotective effects in hippocampal neurogenesis and neurodegeneration. |
URI: | http://doi.org/10.1111/fcp.12165 https://onlinelibrary.wiley.com/doi/10.1111/fcp.12165 http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/2064 |
Appears in Collections: | Temel Tıp Bilimleri |
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