Please use this identifier to cite or link to this item: http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/1991
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dc.contributor.authorAnik, Ihsan-
dc.contributor.authorCabuk, Burak-
dc.contributor.authorCeylan, Savas-
dc.contributor.authorCeylan, Sureyya-
dc.contributor.authorKokturk, Sibel-
dc.date.accessioned2022-08-16T11:42:31Z-
dc.date.available2022-08-16T11:42:31Z-
dc.date.issued2020-
dc.identifier.urihttp://doi.org/10.1016/j.jocn.2019.11.014-
dc.identifier.urihttp://earsiv.odu.edu.tr:8080/xmlui/handle/11489/1991-
dc.description.abstractThis study aimed to determine the anatomical and histological features of diaphragma sellae that affect the suprasellar extension of intrasellar tumours. Twenty-four fresh adult cadavers were dissected for the study. Diaphragma sellae and pituitary capsules with sellar structures were resected. The diaphragma sellae was anatomically reviewed in detail. Immunohistochemical staining was performed for collagen types I, II, Ill, and IV. We examined the suprasellar growth of 13 sellar tumours extending superiorly through the diaphragma sellae by performing a series of 2704 endoscopic transnasal operations to analyse the anatomic and histologic results of the study. The diameter of the foramen of diaphragma sellae varied between specimens. Of 24 specimens, the diaphragma sellae in five (21%) had a tight-type foramen and those in 19 (79%) were more spacious. An increased expression of collagen types I and IV was observed in the pituitary capsule and the diaphragma sellae. In this clinical series, we observed that all types of sellar tumours could expand through the foramen. We observed radiologically and intraoperatively that the diaphragma sellae was displaced laterally and formed a dome in two cases with an adenoma extending to the suprasellar area. Two types of suprasellar extension through the diaphragma sellae are possible: 1) The collagen structure of diaphragma sellae can be destroyed by invasive tumours; 2) The morphology of the foramen of the diaphragma sellae facilitates suprasellar tumoural extension. All sellar tumours, including non-invasive cystic tumours, may invade the suprasellar area by expanding through the foramen of the diaphragma sellae. (C) 2019 Elsevier Ltd. All rights reserved.en_US
dc.language.isoengen_US
dc.publisherELSEVIER SCI LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLANDen_US
dc.relation.isversionof10.1016/j.jocn.2019.11.014en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDiaphragma sellae; Pituitary capsule; Collagen I; Transsphenoidal surgeryen_US
dc.subjectPITUITARY-GLAND; MICROSURGICAL ANATOMY; CAVERNOUS SINUS; GROWTH-PATTERNS; DURAL INVASION; ADENOMAS; MATRIX-METALLOPROTEINASE-9; EXPRESSION; TUMORS; WALLSen_US
dc.titleAnatomic and histologic features of diaphragma sellae that effects the suprasellar extensionen_US
dc.typearticleen_US
dc.relation.journalJOURNAL OF CLINICAL NEUROSCIENCEen_US
dc.contributor.departmentOrdu Üniversitesien_US
dc.contributor.authorID0000-0001-5636-3300en_US
dc.identifier.volume71en_US
dc.identifier.startpage234en_US
dc.identifier.endpage244en_US
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