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Insulin-like growth factor-1 receptor expression in pediatric tumors: a comparative immunohistochemical study

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dc.contributor.author Karakus, Resul
dc.contributor.author Karakus, Esra
dc.contributor.author Emir, Suna
dc.contributor.author Kacar, Ayper
dc.contributor.author Ozyoruk, Derya
dc.date.accessioned 2024-03-26T06:21:32Z
dc.date.available 2024-03-26T06:21:32Z
dc.date.issued 2018
dc.identifier.citation Karakus, R., Karakus, E., Emir, S., Kaçar, A., Özyörük, D. (2018). Insulin-like growth factor-1 receptor expression in pediatric tumors: a comparative immunohistochemical study. Turk. J. Med. Sci., 48(2), 419-423. https://doi.org/10.3906/sag-1801-233 en_US
dc.identifier.issn 1300-0144
dc.identifier.issn 1303-6165
dc.identifier.uri http://dx.doi.org/10.3906/sag-1801-233
dc.identifier.uri https://www.webofscience.com/wos/woscc/full-record/WOS:000431261100032
dc.identifier.uri http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/4982
dc.description WoS Categories: Medicine, General & Internal en_US
dc.description Web of Science Index: Science Citation Index Expanded (SCI-EXPANDED) en_US
dc.description Research Areas: General & Internal Medicine en_US
dc.description.abstract Background/aim: Insulin-like growth factor-1 receptor (IGF-1R) is a pivotal receptor tyrosine kinase involved in the cell cycle and malignant tumor transformation. It is differentially expressed in various types of tumors. We aimed to determine the expression of IGF-1R in different pediatric tumors and to shed light on possible new indications of anti-IGF-1R treatment approaches. Materials and methods: A total of 147 specimens were analyzed according to their expression of IGF-1R. Specimens included those from rhabdomyosarcomas, Wilms tumors, Ewing sarcoma/primitive neuroectodermal tumors, peripheral neuroblastic tumors, acute lymphoblastic lymphoma, Hodgkin lymphoma, Burkitt lymphoma, retinoblastoma, pleuropulmonary blastoma, Langerhans cell histiocytosis, endodermal sinus tumors (ESTs), and myeloid sarcoma. Analysis was performed on tissue sections by immunohistochemically staining for IGF-1R expression. Results: All six specimens of EST cases showed positivity for IGF-R1. Additionally, about 56% of the Hodgkin lymphoma, 80% of the rhabdomyosarcoma, and 70% of the Wilms tumor specimens showed positivity for IGF-R1 expression. Conclusion: All ESTs examined in our study expressed IGF-1R and to our knowledge this is the first report regarding ESTs and IGF-1R expression. IGF-1R could be included among confirmatory markers for ESTs and, from a therapeutic viewpoint, ESTs should also be examined for IGF-1R expression for beneficial regimens. en_US
dc.language.iso eng en_US
dc.publisher Tubitak Scientific & Technological Research Council Turkey-ANKARA en_US
dc.relation.isversionof 10.3906/sag-1801-233 en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.subject Insulin-like growth factor-1 receptor, endodermal sinus tumor, neuroblastoma, Wilms tumor, rhabdomyosarcoma en_US
dc.subject CELL LUNG-CANCER, MONOCLONAL-ANTIBODY, PROTEIN EXPRESSION, COPY NUMBER, RHABDOMYOSARCOMA, OSTEOSARCOMA, SARCOMAS, PATHWAY, IGF-1R, GENE en_US
dc.title Insulin-like growth factor-1 receptor expression in pediatric tumors: a comparative immunohistochemical study en_US
dc.type article en_US
dc.relation.journal TURKISH JOURNAL OF MEDICAL SCIENCES en_US
dc.contributor.department Ordu Üniversitesi en_US
dc.contributor.authorID 0000-0003-2654-6119 en_US
dc.contributor.authorID 0000-0002-9615-6522 en_US
dc.contributor.authorID 0000-0003-2424-3763 en_US
dc.identifier.volume 48 en_US
dc.identifier.issue 2 en_US
dc.identifier.startpage 419 en_US
dc.identifier.endpage 423 en_US


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