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Macular ganglion cell-inner plexiform layer thickness for detection of early retinal toxicity of hydroxychloroquine

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dc.contributor.author Kan, Emrah
dc.contributor.author Yakar, Konuralp
dc.contributor.author Demirag, Mehmet Derya
dc.contributor.author Gok, Mustafa
dc.date.accessioned 2024-03-25T06:18:15Z
dc.date.available 2024-03-25T06:18:15Z
dc.date.issued 2018
dc.identifier.citation Kan, E., Yakar, K., Demirag, MD., Gok, M. (2018). Macular ganglion cell-inner plexiform layer thickness for detection of early retinal toxicity of hydroxychloroquine. Int. Ophthalmol., 38(4), 1635-1640. https://doi.org/10.1007/s10792-017-0635-y en_US
dc.identifier.issn 0165-5701
dc.identifier.issn 1573-2630
dc.identifier.uri http://dx.doi.org/10.1007/s10792-017-0635-y
dc.identifier.uri https://www.webofscience.com/wos/woscc/full-record/WOS:000439166500033
dc.identifier.uri http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/4950
dc.description WoS Categories: Ophthalmology en_US
dc.description Web of Science Index: Science Citation Index Expanded (SCI-EXPANDED) en_US
dc.description Research Areas: Ophthalmology en_US
dc.description.abstract This study evaluated the macular ganglion cell-inner plexiform layer (GC-IPL) thickness using spectral-domain (SD) optical coherence tomography (OCT) in patients with chronic exposure to hydroxychloroquine (HCQ). A total of 90 patients (90 eyes) treated with HCQ for at least 5 years and normal controls were included in the study. A fundus examination, automated threshold perimetry, and GC-IPL thickness measurements using the Cirrus high-definition OCT ganglion cell analysis algorithm were performed in all patients treated with HCQ. Average, minimum, and sectorial macular GC-IPL thicknesses were compared between the patients and controls. There was no statistically significant difference in age or sex between the groups. The anterior segment and fundoscopy were normal in all patients and controls. Visual field (VF) testing was normal in all patients. The average, minimum, and sectorial macular GC-IPL thicknesses were significantly lower in patients than those in control subjects. There was significant thinning of the macular GC-IPL in the absence of clinically evident HCQ-related retinopathy and VF abnormalities. Measurements of the macular GC-IPL thickness using SD-OCT may therefore be useful in the early diagnosis and in monitoring the progression of retinal changes in patients receiving long-term HCQ therapy. en_US
dc.language.iso eng en_US
dc.publisher SPRINGER-DORDRECHT en_US
dc.relation.isversionof 10.1007/s10792-017-0635-y en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.subject Ganglion cell, Retinal toxicity, Hydroxychloroquine, SD-OCT en_US
dc.subject OPTICAL COHERENCE TOMOGRAPHY, CHLOROQUINE RETINOPATHY, PIGMENT-EPITHELIUM, RISK-FACTORS, CESSATION, NERVE, RECOMMENDATIONS, MACULOPATHY, PROGRESSION, EXPOSURE en_US
dc.title Macular ganglion cell-inner plexiform layer thickness for detection of early retinal toxicity of hydroxychloroquine en_US
dc.type article en_US
dc.relation.journal INTERNATIONAL OPHTHALMOLOGY en_US
dc.contributor.department Ordu Üniversitesi en_US
dc.contributor.authorID 0000-0001-5056-4689 en_US
dc.contributor.authorID 0000-0002-3839-5699 en_US
dc.identifier.volume 38 en_US
dc.identifier.issue 4 en_US
dc.identifier.startpage 1635 en_US
dc.identifier.endpage 1640 en_US


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