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Investigation of the nephroprotective effect of dexmedetomidine on colistin-induced nephrotoxicity in rats

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dc.contributor.author Canakci, Ebru
dc.contributor.author Karatas, Ahmet
dc.contributor.author Coskun, Ilker
dc.contributor.author Benli, Erdal
dc.contributor.author Altinbas, Ali
dc.contributor.author Akcay Celik, Muruvvet
dc.contributor.author Bayrak, Tulin
dc.contributor.author Bayrak, Ahmet
dc.date.accessioned 2024-03-20T13:48:15Z
dc.date.available 2024-03-20T13:48:15Z
dc.date.issued 2022
dc.identifier.citation Canakci, E., Karatas, A., Coskun, I., Benli, E., Altinbas, A., Akcay Celik, M., Bayrak, T., Bayrak, A. (2022). Investigation of the nephroprotective effect of dexmedetomidine on colistin-induced nephrotoxicity in rats. Bratisl. Med. J., 123(8), 579-584. https://doi.org/10.4149/BLL_2022_094 en_US
dc.identifier.issn 0006-9248
dc.identifier.issn 1336-0345
dc.identifier.uri http://dx.doi.org/10.4149/BLL_2022_094
dc.identifier.uri https://www.webofscience.com/wos/woscc/full-record/WOS:000835577200006
dc.identifier.uri http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/4814
dc.description WoS Categories: Medicine, General & Internal en_US
dc.description Web of Science Index: Science Citation Index Expanded (SCI-EXPANDED) en_US
dc.description Research Areas: General & Internal Medicine en_US
dc.description.abstract BACKGROUND: There are very few studies in the literature focusing on whether dexmedetomidine exerts a protective effect on colistin nephrotoxicity. Our study aims to investigate the nephroprotective effect of dexmedetomidine in an experimental model of nephrotoxicity in rats. METHODS: The control group was administered saline (SF) intraperitoneally twice a day. The colistin group received an intraperitoneal (ip) injection of 10 mg/kg of colistin twice a day. The DX10 group received 10 mg/ kg of colistin 20 minutes after the intraperitoneal injection of 10 mcg/kg of dexmedetomidine. The DX20 group received 10 mg/kg of colistin 20 minutes after the intraperitoneal injection of 20 mcg/kg of dexmedetomidine. Applications were continued for 7 days, twice a day. All rats were sacrificed on the 8th day after blood and kidney tissue samples were taken. BUN, Creatine, KIM-1 and Endothelin-1 were studied in blood samples. RESULTS: There was a significant difference in the median values of Urea, BUN and Creatine between the groups (p<0.001, p<0.001, p<0.001, respectively). There was a significant difference in the median values of KIM-1 and Endothelin-1 between the groups (p=0.009, p=0.001, respectively). A significant difference was observed between the histopathological scores of the groups (p<0.001). CONCLUSION: Dexmedetomidine significantly decreased the elevated levels of BUN, Creatinine, KIM-1, and Endothelin-1 induced by colistin. Dexmedetomidine, at both doses, histopathologically prevented apoptosis and reduced the number of necrotic cells in the kidneys. Dexmedetomidine provides renoprotective effects, therefore it is a valuable sedation agent for clinicians working in intensive care units (Tab. 2, Fig. 4, Ref. 19). Text in PDF www.elis.sk en_US
dc.description.sponsorship Ordu University Scientific Research Projects Coordination Center (ODU SRPC Project) [A-2102] en_US
dc.language.iso eng en_US
dc.publisher AEPRESS SRO-BRATISLAVA en_US
dc.relation.isversionof 10.4149/BLL_2022_094 en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.subject rat, colistin, nephrotoxicity, dexmedetomidine en_US
dc.subject ISCHEMIA-REPERFUSION INJURY, ACUTE KIDNEY INJURY, RENAL-FUNCTION, INFUSION en_US
dc.title Investigation of the nephroprotective effect of dexmedetomidine on colistin-induced nephrotoxicity in rats en_US
dc.type article en_US
dc.relation.journal BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY en_US
dc.contributor.department Ordu Üniversitesi en_US
dc.contributor.authorID 0000-0001-6781-3522 en_US
dc.contributor.authorID 0000-0002-0193-6965 en_US
dc.identifier.volume 123 en_US
dc.identifier.issue 8 en_US
dc.identifier.startpage 579 en_US
dc.identifier.endpage 584 en_US


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