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Topical tranexamic acid versus autotransfusion after total knee arthroplasty

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dc.contributor.author Guzel, Yunus
dc.contributor.author Gurcan, Osman T.
dc.contributor.author Golge, Umut H.
dc.contributor.author Dulgeroglu, Turan C.
dc.contributor.author Metineren, Hasan
dc.date.accessioned 2024-03-15T08:31:04Z
dc.date.available 2024-03-15T08:31:04Z
dc.date.issued 2016
dc.identifier.citation Guzel, Y., Gurcan, OT., Golge, UH., Dulgeroglu, TC., Metineren, H. (2016). Topical tranexamic acid versus autotransfusion after total knee arthroplasty. J. Orthop. Surg., 24(2), 179-182. https://doi.org/10.1177/1602400212 en_US
dc.identifier.issn 1022-5536
dc.identifier.issn 2309-4990
dc.identifier.uri http://dx.doi.org/10.1177/1602400212
dc.identifier.uri https://www.webofscience.com/wos/woscc/full-record/WOS:000383213900012
dc.identifier.uri http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/4236
dc.description WoS Categories: Orthopedics; Surgery en_US
dc.description Web of Science Index: Science Citation Index Expanded (SCI-EXPANDED) en_US
dc.description Research Areas: Orthopedics; Surgery en_US
dc.description.abstract Purpose. To compare the use of topical tranexamic acid (TXA) with postoperative autologous transfusion (PAT) in terms of blood loss, need for allogeneic blood transfusion, and cost-effectiveness. Methods. Records of 25 men and 125 women (mean age, 67 years) who underwent primary unilateral total knee arthroplasty (TKA) and were randomised to the PAT group (n=50), topical TXA group (n=50), or routine drainage group (control) [n=50] were reviewed. Pre- and post-operative haemoglobin level, total postoperative drainage volume, and the need for allogeneic blood transfusion were recorded. Results. The 3 groups were comparable in terms of age, gender, and preoperative haemoglobin level. The total postoperative drainage volume was lower in the TXA group than the PAT or routine drainage groups (174.48 vs. 735 vs. 760 ml, p<0.001). The postoperative haemoglobin level was lower in the routine drainage group than the PAT or TXA groups on day 1 (11.67 vs. 12.33 vs. 12.40 g/dl, p<0.001) and day 3 (9.9 vs. 10.7 vs. 11.14 g/dl, p<0.001). The number of patients who received allogeneic blood transfusion was higher in the routine drainage group (12 and 4 patients received 1 and 2 units of blood, respectively) than the PAT group (4 patients received 1 unit of blood) or the TXA group (none required transfusion) [p<0.001], and the respective total transfusion cost was $1200, $240, and $0. The total cost was lowest in the TXA group followed by the routine drainage group and PAT group ($200 vs. $1200 vs. $12 390). No patient developed acute infection, deep venous thrombosis, pulmonary embolism, myocardial infarction, or stroke. Conclusion. Compared with PAT, topical TXA was more cost-effective and resulted in less total postoperative drainage volume and less need for allogeneic blood transfusion. en_US
dc.language.iso eng en_US
dc.publisher HONG KONG ACAD MEDICINE PRESS-HONG KONG en_US
dc.relation.isversionof 10.1177/1602400212 en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.subject arthroplasty, replacement, knee, blood loss, surgical, blood transfusion, autologous, hemostasis, surgical, tranexamic acid en_US
dc.subject PRIMARY TOTAL HIP, RANDOMIZED CONTROLLED-TRIAL, REDUCING BLOOD-LOSS, TRANSFUSION DRAIN, NO DRAIN, METAANALYSIS, REPLACEMENT, TOURNIQUET, MANAGEMENT, SURGERY en_US
dc.title Topical tranexamic acid versus autotransfusion after total knee arthroplasty en_US
dc.type article en_US
dc.relation.journal JOURNAL OF ORTHOPAEDIC SURGERY en_US
dc.contributor.department Ordu Üniversitesi en_US
dc.identifier.volume 24 en_US
dc.identifier.issue 2 en_US
dc.identifier.startpage 179 en_US
dc.identifier.endpage 182 en_US


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