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DNA damage and inflammation in COVID-19 cases

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dc.contributor.author Gulbay, Gonca
dc.contributor.author Savrun, Atakan
dc.date.accessioned 2024-03-15T08:28:10Z
dc.date.available 2024-03-15T08:28:10Z
dc.date.issued 2022
dc.identifier.citation Gülbay, G., Savrun, A. (2022). DNA damage and inflammation in COVID-19 cases. Cukurova Med. J., 47(3), 1073-1079. https://doi.org/10.17826/cumj.1102599 en_US
dc.identifier.issn 2602-3032
dc.identifier.issn 2602-3040
dc.identifier.uri http://dx.doi.org/10.17826/cumj.1102599
dc.identifier.uri https://www.webofscience.com/wos/woscc/full-record/WOS:000889635700017
dc.identifier.uri http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/4215
dc.description WoS Categories: Medicine, General & Internal en_US
dc.description Web of Science Index: Emerging Sources Citation Index (ESCI) en_US
dc.description Research Areas: General & Internal Medicine en_US
dc.description.abstract Purpose: The aim of this study is to see oxidative DNA damage (8-OHdG), its relationship with inflammatory mediators (IL6 and TNFA), and its reflections on laboratory findings in patients who had COVID-19 infection at different intensities. Materials and Methods: Serum interleukin-6 (IL6), tumor necrosis factor-alpha (TNFA), and 8-hydroxy-2'deoxyguanosine (8-OHdG) levels were measured using kits based on the enzyme-linked immunosorbent assay (ELISA) principle. Results: In COVID-19 positive patients treated in intensive care 8-OHdG marker level is at the highest level and statistically significant. In patients receiving inpatient treatment in the hospitalized, the 8-OHdG marker level is higher than the control and outpatient groups. IL6 values were at the highest level in the patient group treated in the intensive care unit and were higher than the outpatient and control groups. There was no statistically significant difference between the control and patient groups in terms of TNFA values. Neutrophil-to-lymphocyte ratio (NLR) was lower in the control group than in all patient groups. C-reactive protein (CRP) is higher in hospitalized patients than in the control group. Lactate dehydrogenase (LDH) was found to be statistically significantly higher in hospitalized patients than outpatients. Conclusion: As the severity of COVID-19 increases, serum 8-OHdG and IL6 levels also increase. These parameters can guide the diagnosis of COVID-19 patients in the early stages of the disease course. en_US
dc.description.sponsorship Ordu University Scientific Research Projects Coordination Unit Ordu, Turkey [A2119] en_US
dc.language.iso eng en_US
dc.publisher CUKUROVA UNIV, FAC MEDICINE-ADANA en_US
dc.relation.isversionof 10.17826/cumj.1102599 en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.subject COVID-19, DNA damage, Interleukin-6, Tumor necrosis factor-alpha, 8-hydroxy-2'deoxyguanosine en_US
dc.subject CYTOKINE STORM en_US
dc.title DNA damage and inflammation in COVID-19 cases en_US
dc.type article en_US
dc.relation.journal CUKUROVA MEDICAL JOURNAL en_US
dc.contributor.department Ordu Üniversitesi en_US
dc.identifier.volume 47 en_US
dc.identifier.issue 3 en_US
dc.identifier.startpage 1073 en_US
dc.identifier.endpage 1079 en_US


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