DSpace Repository

Protective effect of metformin on lithium-induced nephrogenic diabetes insipidus: An experimental study in rats

Show simple item record

dc.contributor.author Tas, Halil Ibrahim
dc.contributor.author Sancak, Eyup Burak
dc.date.accessioned 2023-01-06T11:15:18Z
dc.date.available 2023-01-06T11:15:18Z
dc.date.issued 2021
dc.identifier.citation Tas, HI., Sancak, EB. (2021). Protective effect of metformin on lithium-induced nephrogenic diabetes insipidus: An experimental study in rats. Advances in Clinical and Experimental Medicine, 30(11), 1185-1193.Doi:10.17219/acem/140403 en_US
dc.identifier.isbn 1899-5276
dc.identifier.isbn 2451-2680
dc.identifier.uri http://dx.doi.org/10.17219/acem/140403
dc.identifier.uri https://www.webofscience.com/wos/woscc/full-record/WOS:000726649200010
dc.identifier.uri https://pubmed.ncbi.nlm.nih.gov/34595852
dc.identifier.uri http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/3504
dc.description WoS Categories : Medicine, Research & Experimental Web of Science Index : Science Citation Index Expanded (SCI-EXPANDED) Research Areas : Research & Experimental Medicine Open Access Designations : gold en_US
dc.description.abstract Background. Lithium is widely used in the treatment of bipolar disorders and may lead to nephrogenic diabetes insipidus (NDI), following long-term treatment. Metformin is considered the preferred initial therapy for patients with type 2 diabetes mellitus (T2D). Objectives. To investigate the protective effect of metformin on the kidney damage caused by lithium administration. Materials and methods. Using an animal model of chronic lithium-induced NDI, rats were divided into 4 groups: sham, metformin, lithium, and lithium + metformin. The effects of these treatments were examined using serum electrolytes, blood and tissue total antioxidant status, total oxidant status, the oxidative stress index, urine and blood osmolality, and tissue aquaporin-2 (AQP2) levels. Additionally, histopathological changes, including congestion, hydropic swelling, tubular necrosis, tubular atrophy, and Bowman's capsule dilatation, were evaluated. The total histopathological score was obtained by summing the scores for each pathological finding. Results. In the lithium group, biochemical variables indicating NDI, including sodium, chloride and blood osmolality, increased, and urine osmolality decreased, compared to the sham group. With metformin treatment, the blood osmolality decreased from 328.17 mOsm/kg to 306.33 mOsm/kg, and urine osmolality increased from 349.67 mOsm/kg to 754.50 mOsm/kg (p = 0.004 and p = 0.001, respectively). Tissue AQP2 levels decreased with lithium administration but stabilized with metformin treatment. Additionally, in comparison to the lithium group, the total histopathological score in the metformin group declined from 8.0 to 2.0 (p = 0.002). Conclusions. Metformin may help protect the kidneys from lithium-induced NDI through the AQP2 regulating effect and a reduction in oxidative stress. en_US
dc.description.sponsorship Funding Orgs : Canakkale Onsekiz Mart University, The Scientific Research Coordination Unit [2579] Funding Name Preferred : Canakkale Onsekiz Mart University, The Scientific Research Coordination Unit(Canakkale Onsekiz Mart University) Funding Text : This research was supported by Canakkale Onsekiz Mart University, The Scientific Research Coordination Unit, Project No. 2579. The funding bodies had no role in the design of the study and collection, analysis and interpretation of data, or in writing the en_US
dc.language.iso eng en_US
dc.publisher WROCLAW MEDICAL UNIV WROCLAW en_US
dc.relation.isversionof 10.17219/acem/140403 en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.subject metformin; bipolar disorder; aquaporin-2; lithium; nephrogenic diabetes insipidus en_US
dc.title Protective effect of metformin on lithium-induced nephrogenic diabetes insipidus: An experimental study in rats en_US
dc.type article en_US
dc.relation.journal ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE en_US
dc.contributor.department Ordu Üniversitesi en_US
dc.contributor.authorID 0000-0001-5849-9068 en_US
dc.identifier.volume 30 en_US
dc.identifier.issue 11 en_US
dc.identifier.startpage 1185 en_US
dc.identifier.endpage 1193 en_US


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse

My Account