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Efficacy of ultrasound-guided Transversus Abdominis Plane (TAP) block in inguinal hernia surgery and the immunomodulatory effects of proinflammatory cytokines: prospective, randomized, placebo-controlled study

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dc.contributor.author Canakci, Ebru
dc.contributor.author Cihan, Murat
dc.contributor.author Altinbas, Ali
dc.contributor.author Cebeci, Zubeyir
dc.contributor.author Gultekin, Ahmet
dc.contributor.author Tas, Nilay
dc.date.accessioned 2023-01-06T11:10:01Z
dc.date.available 2023-01-06T11:10:01Z
dc.date.issued 2021
dc.identifier.citation Canakci, E., Cihan, M., Altinbas, A., Cebeci, Z., Gultekin, A., Tas, N. (2021). Efficacy of ultrasound-guided Transversus Abdominis Plane (TAP) block in inguinal hernia surgery and the immunomodulatory effects of proinflammatory cytokines: prospective, randomized, placebo-controlled study. Brazilian Journal of Anesthesiology, 71(5), 538-544.Doi:10.1016/j.bjane.2021.02.005 en_US
dc.identifier.isbn 0104-0014
dc.identifier.isbn 2352-2291
dc.identifier.uri http://dx.doi.org/10.1016/j.bjane.2021.02.005
dc.identifier.uri https://www.webofscience.com/wos/woscc/full-record/WOS:000739668300012
dc.identifier.uri https://pubmed.ncbi.nlm.nih.gov/34537124
dc.identifier.uri http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/3484
dc.description WoS Categories : Anesthesiology Web of Science Index : Science Citation Index Expanded (SCI-EXPANDED) Research Areas : Anesthesiology Open Access Designations : gold, Green Published en_US
dc.description.abstract Background: Tumor Necrosis Factor -a (TNF-a) and Interleukin-113 (IL-113) are among the cytokines released secondary to the surgical stress response. The objective of this study was to investigate the effect of a Transversus Abdominis Plane (TAP) block on postoperative pain and its immunomodulatory activity through proinflammatory cytokines. Methods: TAP (study group; n = 40) or p-TAP (placebo group; n = 40). Patients in the TAP group underwent an Ultrasound (US) guided unilateral TAP block using 20-cc 0.5% bupivacaine solution. Patients in the p-TAP group underwent a sham block using 20-cc isotonic solution. The TNF-a and IL-113 levels were measured three times at preoperative hour-0 and postoperative hours 4 and 24. Visual Analog Scale (VAS) scores were recorded at 0-hours, 30-minutes, 4-hours, and 24-hours. Analgesic use within the first 24-hours following surgery was monitored. Results: The postoperative VAS score was decreased in the TAP group at all time points (0, 4, and 24 hours), and the differences between groups were statistically significant (p < 0.001 for all comparisons). In the TAP group, the TNF-a and IL-113 levels at 4 and 24 hours post operation were significantly lower than the preoperative levels (p < 0.001 for all comparisons). Conclusion: The TAP block for pre-emptive analgesia enabled effective hemodynamic control during the intraoperative period, provided effective pain control in the postoperative period, and decreased inflammation and surgical stress due to the decreased levels of the proinflamma-tory cytokines TNF-ec and IL-1 beta in the first postoperative 24 hours, indicating immunomodulatory effect. (c) 2021 Published by Elsevier Editora Ltda. on behalf of Sociedade Brasileira de Anestesiologia. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/ licenses/by-nc-nd/4.0/). en_US
dc.language.iso eng en_US
dc.publisher ELSEVIER SCIENCE INC NEW YORK en_US
dc.relation.isversionof 10.1016/j.bjane.2021.02.005 en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.subject NEUROENDOCRINE STRESS-RESPONSE; ANALGESIC EFFICACY; REPAIR en_US
dc.subject Immunomodulation; Pain control; Proinflammatory cytokines; Transversus abdominis plane block en_US
dc.title Efficacy of ultrasound-guided Transversus Abdominis Plane (TAP) block in inguinal hernia surgery and the immunomodulatory effects of proinflammatory cytokines: prospective, randomized, placebo-controlled study en_US
dc.type article en_US
dc.relation.journal BRAZILIAN JOURNAL OF ANESTHESIOLOGY en_US
dc.contributor.department Ordu Üniversitesi en_US
dc.contributor.authorID 0000-0001-6611-7226 en_US
dc.contributor.authorID 0000-0003-2093-9229 en_US
dc.contributor.authorID 0000-0001-7862-4268 en_US
dc.identifier.volume 71 en_US
dc.identifier.issue 5 en_US
dc.identifier.startpage 538 en_US
dc.identifier.endpage 544 en_US


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