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Evaluation of Fibrosis and Histopathological Changes in the Psoas Muscle with E- Cadherin, Claudin-5 Expression and Demographic Data: An Autopsy Study

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dc.contributor.author Erdem, Havva
dc.contributor.author Teke, Hacer Yasar
dc.contributor.author Sahin, Yusuf
dc.date.accessioned 2023-01-06T10:58:21Z
dc.date.available 2023-01-06T10:58:21Z
dc.date.issued 2021
dc.identifier.citation Erdem, H., Teke, HY., Sahin, Y. (2021). Evaluation of Fibrosis and Histopathological Changes in the Psoas Muscle with E- Cadherin, Claudin-5 Expression and Demographic Data: An Autopsy Study. Haseki Tip Bulteni-Medical Bulletin of Haseki, 59(4), 280-285.Doi:10.4274/haseki.galenos.2021.7174 en_US
dc.identifier.isbn 1302-0072
dc.identifier.isbn 2147-2688
dc.identifier.uri http://dx.doi.org/10.4274/haseki.galenos.2021.7174
dc.identifier.uri https://www.webofscience.com/wos/woscc/full-record/WOS:000692326800003
dc.identifier.uri http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/3428
dc.description WoS Categories : Medicine, General & Internal Web of Science Index : Emerging Sources Citation Index (ESCI) Research Areas : General & Internal Medicine Open Access Designations : gold en_US
dc.description.abstract Aim: It is known that muscle mass decreases with age. Sometimes it may be possible to adversely affect this reduction. It was aimed to investigate the contribution of claudin-5 and E-cadherin to this process. Methods: Samples were taken from the psoas muscle of 55 cases autopsied for different reasons between 2018-2019. Age, gender, weight, height, chronic disease, and addiction were recorded. Histopathological degeneration parameters were evaluated. In addition, samples were prepared for immunohistochemical study. Evaluation for E-cadherin and claudin-5; no staining, weak staining, moderate staining and severe staining. Fibrosis was evaluated with Masson trichrome. Results: There was a very strong and statistically significant inverse relationship between acidophilic sarcoplasma and staining with claudin-5 (p<0.01). There was also a strong positive correlation between cellular fatty cell degeneration status and staining with claudin-5 (p=0.04). No correlation could be established between sociodemographic characteristics of the cases and staining with claudin-5 and E-cadherin, nor could there be a correlation between staining with E-cadherin and staining with claudin-5 (p>0.05). Conclusion: Claudin-5 can be a target protein that can be used in the detection and prophylaxis of degeneration and atrophy in striated muscles. en_US
dc.language.iso eng en_US
dc.publisher GALENOS YAYINCILIK FINDIKZADE en_US
dc.relation.isversionof 10.4274/haseki.galenos.2021.7174 en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.subject TIGHT; STRANDS; AGE en_US
dc.subject Claudin-5; cadherins; socioeconomic factors; muscle; striated en_US
dc.title Evaluation of Fibrosis and Histopathological Changes in the Psoas Muscle with E- Cadherin, Claudin-5 Expression and Demographic Data: An Autopsy Study en_US
dc.type article en_US
dc.relation.journal HASEKI TIP BULTENI-MEDICAL BULLETIN OF HASEKI en_US
dc.contributor.department Ordu Üniversitesi en_US
dc.contributor.authorID 0000-0003-2311-5145 en_US
dc.contributor.authorID 0000-0002-3074-0240 en_US
dc.identifier.volume 59 en_US
dc.identifier.issue 4 en_US
dc.identifier.startpage 280 en_US
dc.identifier.endpage 285 en_US


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