DSpace Repository

Impact of high dose chemoimmunotherapy after surgery on the overall and disease-free survivals in u advanced stage malignant melanoma

Show simple item record

dc.contributor.author Bilgin, Caglar
dc.contributor.author Cetinkunar, Suleyman
dc.contributor.author Bilgen, Koksal
dc.contributor.author Celep, Bahadir
dc.contributor.author Tokgoz, Serhat
dc.contributor.author Sozen, Selim
dc.contributor.author Karaca, Turgut
dc.contributor.author Ozer, Saadet
dc.contributor.author Tunc, Gunduz
dc.date.accessioned 2022-09-13T05:57:56Z
dc.date.available 2022-09-13T05:57:56Z
dc.date.issued 2013
dc.identifier.uri https://pubmed.ncbi.nlm.nih.gov/23027639/
dc.identifier.uri http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/3262
dc.description.abstract BACKGROUND: To investigate the impact of high dose chemoimmunotherapy in addition to surgery on the cumulative survival and disease-free survey of malignant melanoma patients. METHODS: A total of 86 malignant melanoma patients [35 females (40.7%), 51 males (59.3%), mean age: 55.5] were treated according to their stages between Februrary 1997 and June 2007 After surgery, adjuvant immunotherapy was applied to patients in Stage 2, while adjuvant chemotherapy and adjuvan immunotherapy were administered to those at Stages 3 and 4. RESULTS: Overall rate of mortality was 31.4% (27/86). The most frequent postoperative complications were wound infection (n=8, 9.3%) in the early period and lymphedema in lower extremities (n=4, 4.6%) in the late period. Temporary and tolerable complications ensourcing from chemoimmunotherapy were encountered in 9 (10.4%) patients. The survival rates and disease-free periods of combined treatment protocol were found to be similar to those in ECOG 1684 and ECOG 1690 studies. CONCLUSION: Adjuvant immunotherapy and chemoimmunotherapy seem to improve overall survival and disease-free survey in malignant melanoma. Further clinical studies are necessary to demonstrate the actual effectivity of this promising protocol in the management of malignant melanoma. en_US
dc.language.iso eng en_US
dc.publisher EDIZIONI LUIGI POZZIVIA PANAMA 68, 00198 ROME, ITALY en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.subject Adjuvant Chemotherapy Immunotherapy Malignant melanoma Surgery Survival en_US
dc.title Impact of high dose chemoimmunotherapy after surgery on the overall and disease-free survivals in u advanced stage malignant melanoma en_US
dc.type article en_US
dc.relation.journal ANNALI ITALIANI DI CHIRURGIA en_US
dc.contributor.department Ordu Üniversitesi en_US
dc.contributor.authorID 0000-0003-2006-9198 en_US
dc.contributor.authorID 0000-0003-2716-6222 en_US
dc.contributor.authorID 0000-0001-5366-2292 en_US
dc.identifier.volume 83 en_US
dc.identifier.issue 6 en_US
dc.identifier.startpage 529 en_US
dc.identifier.endpage 533 en_US


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse

My Account