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Cytogenetic effects of commercial formulations of deltamethrin and/or thiacloprid on wistar rat bone marrow cells

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dc.contributor.author Sekeroglu, Vedat
dc.contributor.author Sekeroglu, Zulal Atli
dc.contributor.author Kefelioglu, Haluk
dc.date.accessioned 2022-09-06T10:43:47Z
dc.date.available 2022-09-06T10:43:47Z
dc.date.issued 2013
dc.identifier.uri http://doi.org/10.1002/tox.20746
dc.identifier.uri http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/3188
dc.description.abstract Deltamethrin (DEL) and thiacloprid (THIA) are two insecticides that are widely used in agriculture either separately or in combination. Studies on genotoxicity and cytotoxicity of TIA and the mixture of DEL and THIA insecticides have not been reported so far. Therefore, we investigated the cytotoxic and genotoxic effects of commercial formulations DEL and/or THIA in rat bone marrow cells, using mitotic index (MI), micronucleus (MN) and chromosome aberrations (CA) assay. In vivo cytokinesis-block micronucleus (CBMN) assay using cytochalasin-B in bone marrow cells was performed for the first time in this study. Rats were orally gavaged with a single dose of DEL (15 mg/kg), THIA (112.5 mg/kg) or DEL + THIA (15 + 112.5 mg/kg) for 24 h (acute treatments), or DEL (3 mg/kg/day), THIA (22.5 mg/kg/day) or DEL + THIA (3 + 22.5 mg/kg/day) for 30 days (subacute treatments). A corn oil vehicle control group and cyclophosphamide (50 mg/kg) positive control group were also included. All DEL and/or THIA treatments significantly decreased MI and binucleated (BN) cell numbers, and significantly increased CA, as compared to the vehicle control group. The results of CBMN assay indicated that the combination of DEL and THIA for both treatment times and the 30-day treatment with THIA alone caused a significant increase in micronucleus formation in BN cells. The present findings indicated the combined exposure of DEL and THIA showed genotoxic and cytotoxic effects more than those of individual exposure of DEL or THIA in rat bone marrow cells. © 2011 Wiley Periodicals, Inc. Environ Toxicol 28: 524–531, 2013. en_US
dc.language.iso eng en_US
dc.publisher WILEY111 RIVER ST, HOBOKEN 07030-5774, NJ en_US
dc.relation.isversionof 10.1002/tox.20746 en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.subject deltamethrin, thiacloprid, chromosomal aberrations, micronucleus, rat bone marrow en_US
dc.title Cytogenetic effects of commercial formulations of deltamethrin and/or thiacloprid on wistar rat bone marrow cells en_US
dc.type article en_US
dc.relation.journal ENVIRONMENTAL TOXICOLOGY en_US
dc.contributor.department Ordu Üniversitesi en_US
dc.contributor.authorID 0000-0002-8547-6571 en_US
dc.contributor.authorID 0000-0002-7421-6037 en_US
dc.contributor.authorID 0000-0002-3552-3819 en_US
dc.identifier.volume 28 en_US
dc.identifier.issue 9 en_US
dc.identifier.startpage 524 en_US
dc.identifier.endpage 531 en_US


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