DSpace Repository

Oxcarbazepine-induced cytotoxicity and genotoxicity in human lymphocyte cultures with or without metabolic activation

Show simple item record

dc.contributor.author Delmecioglu, Berrin
dc.contributor.author Kefelioglu, Haluk
dc.contributor.author Sekeroglu, Vedat
dc.contributor.author Sekeroglu, Zulal Atli
dc.contributor.author Yedier, Seval Kontas
dc.date.accessioned 2022-08-19T12:25:40Z
dc.date.available 2022-08-19T12:25:40Z
dc.date.issued 2017
dc.identifier.uri http://doi.org/10.1080/15376516.2016.1273430
dc.identifier.uri https://www.tandfonline.com/doi/full/10.1080/15376516.2016.1273430
dc.identifier.uri http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/2996
dc.description.abstract There has been considerable debate about the relationship between epilepsy and cancer. Oxcarbazepine (OXC) is used for treating certain types of seizures in patients with epilepsy. There have been no detailed investigations about genotoxicity of OXC and its metabolites. Therefore, the aim of this study is to investigate the cytotoxic and genotoxic effects of OXC and its metabolites on cultured human lymphocytes. The cytotoxicity and genotoxicity of OXC on human peripheral blood lymphocytes were examined in vitro by sister chromatid exchange (SCE), chromosomal aberration (CA) and micronucleus (MN) tests. Cultures were treated with 125, 250 and 500 mu g/ml of OXC in the presence (3 h treatment) and absence (24 h and 48 h treatment) of a metabolic activator (S9 mix). Dimethyl sulfoxide (DMSO) was used as a solvent control. OXC showed cytotoxic activities due to significant decreases in mitotic index (MI), proliferation index (PI) and nuclear division index (NDI) in the absence of S9 mix when compared with solvent control. Metabolites of OXC also significantly reduced MI and PI in cultures with S9 mix. OXC significantly increased the CAs, aberrant cells, SCE and MN values in the presence and absence of S9 mix. Our results indicated that both OXC and its metabolites have cytotoxic, cytostatic and genotoxic potential on human peripheral blood lymphocyte cultures under the experimental conditions. Further studies are necessary to elucidate the relationship between cytotoxic, cytostatic and genotoxic effects, and to make a possible risk assessment in patients receiving therapy with this drug. en_US
dc.language.iso eng en_US
dc.publisher TAYLOR & FRANCIS LTD, 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND en_US
dc.relation.isversionof 10.1080/15376516.2016.1273430 en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.subject ANTIEPILEPTIC DRUGS; IN-VITRO; CARBAMAZEPINE; EPILEPSY; LIVER en_US
dc.subject Oxcarbazepine; cytotoxicity; chromosome aberration; micronucleus; sister chromatid exchange en_US
dc.title Oxcarbazepine-induced cytotoxicity and genotoxicity in human lymphocyte cultures with or without metabolic activation en_US
dc.type article en_US
dc.relation.journal TOXICOLOGY MECHANISMS AND METHODS en_US
dc.contributor.department Ordu Üniversitesi en_US
dc.contributor.authorID 0000-0002-3552-3819 en_US
dc.contributor.authorID 0000-0002-7421-6037 en_US
dc.contributor.authorID 0000-0003-3532-573X en_US
dc.identifier.volume 27 en_US
dc.identifier.issue 3 en_US
dc.identifier.startpage 201 en_US
dc.identifier.endpage 206 en_US


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse

My Account