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Dickkopf-1 Levels in Turkish Patients with Bladder Cancer and its Association with Clinicopathological Features

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dc.contributor.author Benli, Erdal
dc.contributor.author Gecit, Ilhan
dc.contributor.author Gunes, Mustafa
dc.contributor.author Kaba, Mehmet
dc.contributor.author Kemik, Ahu Sarbay
dc.contributor.author Pirincci, Necip
dc.contributor.author Tok, Adem
dc.contributor.author Yuksel, Mehmet Bilgehan
dc.date.accessioned 2022-08-17T07:05:44Z
dc.date.available 2022-08-17T07:05:44Z
dc.date.issued 2014
dc.identifier.uri http://doi.org/10.7314/APJCP.2014.15.1.381
dc.identifier.uri http://earsiv.odu.edu.tr:8080/xmlui/handle/11489/2685
dc.description.abstract Background: Evidence indicates that Dickkopf-1 (DKK-1) levels may be a biomarker for cancer risk. The aim of this study was to assess DKK-1 and its correlation with clinic-pathological features in patients with bladder cancer. Materials and Methods: DKK-1 levels were determined in serum samples from 90 patients with bladder cancer before transurethral tumor resection. The concentrations of DKK-1 were determined by using enzyme linked immune-sorbent assay (ELISA). Results: Elevated preoperative DKK-1 levels were associated with tumor stage (p<0.001), grade (p<0.001) and histological grade (p<0.001). Conclusions: The results of our study demonstrated that the level of serum DKK-1 is correlated with both disease progression and increase in the tumor grade. Preoperative serum DKK-1 elevation may thus represent a novel marker for the determination of bladder cancer and the detection of patients with a likely poor clinical outcome. en_US
dc.language.iso eng en_US
dc.publisher ASIAN PACIFIC ORGANIZATION CANCER PREVENTIONAPJCP HEAD OFFICE, KOREAN NATL CANCER CENTER, 323 ILAN -RO, ILSANDONG-GU, GOYANG-SI, GYEONGGI-DO 410-769, SOUTH KOREA en_US
dc.relation.isversionof 10.7314/APJCP.2014.15.1.381 en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.subject Bladder cancerDKK-1clinic-pathological featuresprognosisTurkey en_US
dc.title Dickkopf-1 Levels in Turkish Patients with Bladder Cancer and its Association with Clinicopathological Features en_US
dc.type article en_US
dc.relation.journal ASIAN PACIFIC JOURNAL OF CANCER PREVENTION en_US
dc.contributor.department Ordu Üniversitesi en_US
dc.contributor.authorID 0000-0001-7329-6971 en_US
dc.contributor.authorID 0000-0002-5494-0984 en_US
dc.contributor.authorID 0000-0002-5968-7981 en_US
dc.contributor.authorID 0000-0003-2044-9086 en_US
dc.identifier.volume 15 en_US
dc.identifier.issue 1 en_US
dc.identifier.startpage 381 en_US
dc.identifier.endpage 384 en_US


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